Detalhe da pesquisa
1.
Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.
N Engl J Med
; 371(11): 1005-15, 2014 Sep 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25207766
2.
MicroRNAs Form Triplexes with Double Stranded DNA at Sequence-Specific Binding Sites; a Eukaryotic Mechanism via which microRNAs Could Directly Alter Gene Expression.
PLoS Comput Biol
; 12(2): e1004744, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26844769
3.
Loss of TBL1XR1 disrupts glucocorticoid receptor recruitment to chromatin and results in glucocorticoid resistance in a B-lymphoblastic leukemia model.
J Biol Chem
; 289(30): 20502-15, 2014 Jul 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-24895125
4.
Association of an inherited genetic variant with vincristine-related peripheral neuropathy in children with acute lymphoblastic leukemia.
JAMA
; 313(8): 815-23, 2015 Feb 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-25710658
5.
PACSIN2 polymorphism influences TPMT activity and mercaptopurine-related gastrointestinal toxicity.
Hum Mol Genet
; 21(21): 4793-804, 2012 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22846425
6.
"Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets.
Pharmacol Rev
; 60(2): 181-95, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18552276
7.
Identification of small molecules that mitigate vincristine-induced neurotoxicity while sensitizing leukemia cells to vincristine.
Clin Transl Sci
; 14(4): 1490-1504, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33742760
8.
A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia.
Blood
; 112(4): 1382-91, 2008 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18511810
9.
Pharmacogenomics in pediatric leukemia.
Curr Opin Pediatr
; 22(6): 703-10, 2010 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-20861736
10.
Pharmacogenomics of intracellular methotrexate polyglutamates in patients' leukemia cells in vivo.
J Clin Invest
; 130(12): 6600-6615, 2020 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33164984
11.
Integrative genomic analyses reveal mechanisms of glucocorticoid resistance in acute lymphoblastic leukemia.
Nat Cancer
; 1(3): 329-344, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32885175
12.
Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal.
FASEB J
; 22(8): 2629-38, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18362204
13.
EGF regulates plasminogen activator inhibitor-1 (PAI-1) by a pathway involving c-Src, PKCdelta, and sphingosine kinase 1 in glioblastoma cells.
FASEB J
; 22(2): 455-65, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17855624
14.
Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases.
Biochim Biophys Acta
; 1758(12): 2016-26, 2006 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-16996023
15.
A p53-regulated apoptotic gene signature predicts treatment response and outcome in pediatric acute lymphoblastic leukemia.
Cancer Manag Res
; 9: 397-410, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28979163
16.
Inflammasome-mediated glucocorticoid resistance: The receptor rheostat.
Mol Cell Oncol
; 3(1): e1065947, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-27308575
17.
Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells.
FEBS Lett
; 579(24): 5313-7, 2005 Oct 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-16194537
18.
Antileukemic Efficacy of Continuous vs Discontinuous Dexamethasone in Murine Models of Acute Lymphoblastic Leukemia.
PLoS One
; 10(8): e0135134, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26252865
19.
NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells.
Nat Genet
; 47(6): 607-14, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25938942
20.
The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2.
FEBS Lett
; 554(1-2): 189-93, 2003 Nov 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-14596938