Detalhe da pesquisa
1.
Field evaluation of a mobile biosafety laboratory in Senegal to strengthen rapid disease outbreak response and monitoring.
Afr J Lab Med
; 9(2): 1041, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32934915
2.
Encoding microcarriers: present and future technologies.
Nat Rev Drug Discov
; 1(6): 447-56, 2002 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-12119746
3.
Aspects of successful drug discovery and development.
Antiviral Res
; 71(2-3): 77-89, 2006 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16828174
4.
4-Benzyl and 4-benzoyl-3-dimethylaminopyridin-2(1H)-ones: in vitro evaluation of new C-3-amino-substituted and C-5,6-alkyl-substituted analogues against clinically important HIV mutant strains.
J Med Chem
; 48(6): 1948-64, 2005 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-15771439
5.
In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, rilpivirine).
J Med Chem
; 48(6): 1901-9, 2005 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-15771434
6.
Design, synthesis, and SAR of a novel pyrazinone series with non-nucleoside HIV-1 reverse transcriptase inhibitory activity.
J Med Chem
; 48(6): 1910-8, 2005 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-15771435
7.
Design of HIV-1 protease inhibitors active on multidrug-resistant virus.
J Med Chem
; 48(6): 1965-73, 2005 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-15771440
8.
Synthesis of novel diarylpyrimidine analogues and their antiviral activity against human immunodeficiency virus type 1.
J Med Chem
; 48(6): 2072-9, 2005 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-15771449
9.
Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor.
J Med Chem
; 48(6): 1813-22, 2005 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-15771427
10.
Development of a homogeneous screening assay for automated detection of antiviral agents active against severe acute respiratory syndrome-associated coronavirus.
J Virol Methods
; 129(1): 56-63, 2005 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-15961169
11.
New non-nucleoside reverse transcriptase inhibitors (NNRTIs) in development for the treatment of HIV infections.
Curr Opin Pharmacol
; 4(5): 437-46, 2004 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-15351347
12.
4-benzyl- and 4-benzoyl-3-dimethylaminopyridin-2(1H)-ones, a new family of potent anti-HIV agents: optimization and in vitro evaluation against clinically important HIV mutant strains.
J Med Chem
; 47(22): 5501-14, 2004 Oct 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-15481987
13.
Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants.
J Med Chem
; 47(10): 2550-60, 2004 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-15115397
14.
A time-of-drug addition approach to target identification of antiviral compounds.
Nat Protoc
; 6(6): 925-33, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21637207
15.
TMC114, a novel human immunodeficiency virus type 1 protease inhibitor active against protease inhibitor-resistant viruses, including a broad range of clinical isolates.
Antimicrob Agents Chemother
; 49(6): 2314-21, 2005 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-15917527
16.
TMC125 displays a high genetic barrier to the development of resistance: evidence from in vitro selection experiments.
J Virol
; 79(20): 12773-82, 2005 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-16188980
17.
Encoding microcarriers by spatial selective photobleaching.
Nat Mater
; 2(3): 169-73, 2003 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-12612674
18.
TMC125, a novel next-generation nonnucleoside reverse transcriptase inhibitor active against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus type 1.
Antimicrob Agents Chemother
; 48(12): 4680-6, 2004 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-15561844
19.
On the detection of multiple-binding modes of ligands to proteins, from biological, structural, and modeling data.
J Comput Aided Mol Des
; 17(2-4): 129-34, 2003.
Artigo
em Inglês
| MEDLINE | ID: mdl-13677481