Detalhe da pesquisa
1.
Maintained therapeutic effect of revefenacin over 52 weeks in moderate to very severe Chronic Obstructive Pulmonary Disease (COPD).
Respir Res
; 20(1): 241, 2019 Oct 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-31666076
2.
Cardiovascular safety of revefenacin, a once-daily, lung-selective, long-acting muscarinic antagonist for nebulized therapy of chronic obstructive pulmonary disease: Evaluation in phase 3 clinical trials.
Pulm Pharmacol Ther
; 57: 101808, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31152911
3.
Hyperoxia-induced p47phox activation and ROS generation is mediated through S1P transporter Spns2, and S1P/S1P1&2 signaling axis in lung endothelium.
Am J Physiol Lung Cell Mol Physiol
; 311(2): L337-51, 2016 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27343196
4.
Sphingosine kinase 1 deficiency confers protection against hyperoxia-induced bronchopulmonary dysplasia in a murine model: role of S1P signaling and Nox proteins.
Am J Pathol
; 183(4): 1169-1182, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23933064
5.
Targeting sphingosine kinase 1 attenuates bleomycin-induced pulmonary fibrosis.
FASEB J
; 27(4): 1749-60, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23315259
6.
Novel role for non-muscle myosin light chain kinase (MLCK) in hyperoxia-induced recruitment of cytoskeletal proteins, NADPH oxidase activation, and reactive oxygen species generation in lung endothelium.
J Biol Chem
; 287(12): 9360-75, 2012 Mar 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-22219181
7.
Protection of LPS-induced murine acute lung injury by sphingosine-1-phosphate lyase suppression.
Am J Respir Cell Mol Biol
; 45(2): 426-35, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21148740
8.
Particulate matter disrupts human lung endothelial barrier integrity via ROS- and p38 MAPK-dependent pathways.
Am J Respir Cell Mol Biol
; 42(4): 442-9, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19520919
9.
Dynamin 2 and c-Abl are novel regulators of hyperoxia-mediated NADPH oxidase activation and reactive oxygen species production in caveolin-enriched microdomains of the endothelium.
J Biol Chem
; 284(50): 34964-75, 2009 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-19833721
10.
Revefenacin, a Long-Acting Muscarinic Antagonist, Does Not Prolong QT Interval in Healthy Subjects: Results of a Placebo- and Positive-Controlled Thorough QT Study.
Clin Pharmacol Drug Dev
; 9(1): 130-139, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31468714
11.
Role of lysophosphatidic acid receptor LPA2 in the development of allergic airway inflammation in a murine model of asthma.
Respir Res
; 10: 114, 2009 Nov 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-19930563
12.
Pharmacokinetics and safety of revefenacin in subjects with impaired renal or hepatic function.
Int J Chron Obstruct Pulmon Dis
; 14: 2305-2318, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31632000
13.
Nebulized Versus Dry Powder Long-Acting Muscarinic Antagonist Bronchodilators in Patients With COPD and Suboptimal Peak Inspiratory Flow Rate.
Chronic Obstr Pulm Dis
; 6(4)2019 Oct 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31647854
14.
Data on the safety and tolerability of revefenacin, in patients with moderate to very severe chronic obstructive pulmonary disease.
Data Brief
; 26: 104277, 2019 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-31534988
15.
Improvements in Lung Function with Nebulized Revefenacin in the Treatment of Patients with Moderate to Very Severe COPD: Results from Two Replicate Phase III Clinical Trials.
Chronic Obstr Pulm Dis
; 6(2): 154-165, 2019 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30974049
16.
Revefenacin, a once-daily, lung-selective, long-acting muscarinic antagonist for nebulized therapy: Safety and tolerability results of a 52-week phase 3 trial in moderate to very severe chronic obstructive pulmonary disease.
Respir Med
; 153: 38-43, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31150963
17.
Oxygen sensing by primary cardiac fibroblasts: a key role of p21(Waf1/Cip1/Sdi1).
Circ Res
; 92(3): 264-71, 2003 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-12595337
18.
Coronin 1B regulates S1P-induced human lung endothelial cell chemotaxis: role of PLD2, protein kinase C and Rac1 signal transduction.
PLoS One
; 8(5): e63007, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23667561
19.
Sphingosine kinase 1 is required for mesothelioma cell proliferation: role of histone acetylation.
PLoS One
; 7(9): e45330, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-23028939
20.
FoxM1 mediates the progenitor function of type II epithelial cells in repairing alveolar injury induced by Pseudomonas aeruginosa.
J Exp Med
; 208(7): 1473-84, 2011 Jul 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-21708928