Detalhe da pesquisa
1.
Population pharmacokinetic modeling of dolutegravir/lamivudine to support a once-daily fixed-dose combination regimen in virologically suppressed adults living with HIV-1.
Antimicrob Agents Chemother
; 68(5): e0150423, 2024 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38587380
2.
Lack of pharmacokinetic interaction between the HIV-1 maturation inhibitor GSK3640254 and combination oral contraceptives in healthy women.
Br J Clin Pharmacol
; 88(4): 1704-1712, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34427938
3.
A Phase I Evaluation of the Pharmacokinetics and Tolerability of the HIV-1 Maturation Inhibitor GSK3640254 and Tenofovir Alafenamide/Emtricitabine in Healthy Participants.
Antimicrob Agents Chemother
; 65(6)2021 05 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33753329
4.
Phase I evaluation of pharmacokinetics and tolerability of the HIV-1 maturation inhibitor GSK3640254 and dolutegravir in healthy adults.
Br J Clin Pharmacol
; 87(9): 3501-3507, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33533507
5.
Conformational disturbance in Abl kinase upon mutation and deregulation.
Proc Natl Acad Sci U S A
; 106(5): 1386-91, 2009 Feb 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-19164531
6.
Relative Bioavailability and Food Effect of GSK3640254 Tablet and Capsule Formulations in Healthy Participants.
Clin Pharmacol Drug Dev
; 11(5): 632-639, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34995417
7.
Expression of a Src family kinase in chronic myelogenous leukemia cells induces resistance to imatinib in a kinase-dependent manner.
J Biol Chem
; 285(28): 21446-57, 2010 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-20452982
8.
Phase I Study of the Novel Enhancer of Zeste Homolog 2 (EZH2) Inhibitor GSK2816126 in Patients with Advanced Hematologic and Solid Tumors.
Clin Cancer Res
; 25(24): 7331-7339, 2019 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31471312
9.
Safety, efficacy, and dose response of the maturation inhibitor GSK3532795 (formerly known as BMS-955176) plus tenofovir/emtricitabine once daily in treatment-naive HIV-1-infected adults: Week 24 primary analysis from a randomized Phase IIb trial.
PLoS One
; 13(10): e0205368, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30352054
10.
HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, Hck.
BMC Chem Biol
; 12: 1, 2012 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22420777