Detalhe da pesquisa
1.
A bioengineered probiotic for the oral delivery of a peptide Kv1.3 channel blocker to treat rheumatoid arthritis.
Proc Natl Acad Sci U S A
; 120(2): e2211977120, 2023 01 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36595694
2.
The molecular evolution of feathers with direct evidence from fossils.
Proc Natl Acad Sci U S A
; 116(8): 3018-3023, 2019 02 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30692253
3.
Comprehensive engineering of the tarantula venom peptide huwentoxin-IV to inhibit the human voltage-gated sodium channel hNav1.7.
J Biol Chem
; 295(5): 1315-1327, 2020 01 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-31871053
4.
Biophysical basis for Kv1.3 regulation of membrane potential changes induced by P2X4-mediated calcium entry in microglia.
Glia
; 68(11): 2377-2394, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32525239
5.
Reinvestigation of the biological activity of d-allo-ShK protein.
J Biol Chem
; 292(30): 12599-12605, 2017 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-28596383
6.
Targeting KCa1.1 Channels with a Scorpion Venom Peptide for the Therapy of Rat Models of Rheumatoid Arthritis.
J Pharmacol Exp Ther
; 365(2): 227-236, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29453198
7.
KCa1.1 channels regulate ß1-integrin function and cell adhesion in rheumatoid arthritis fibroblast-like synoviocytes.
FASEB J
; 31(8): 3309-3320, 2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28428266
8.
Peptide therapeutics from venom: Current status and potential.
Bioorg Med Chem
; 26(10): 2738-2758, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28988749
9.
The Single Disulfide-Directed ß-Hairpin Fold. Dynamics, Stability, and Engineering.
Biochemistry
; 56(19): 2455-2466, 2017 05 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-28437072
10.
Prolonged immunomodulation in inflammatory arthritis using the selective Kv1.3 channel blocker HsTX1[R14A] and its PEGylated analog.
Clin Immunol
; 180: 45-57, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28389388
11.
A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation.
J Neuroinflammation
; 14(1): 128, 2017 06 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28651603
12.
Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block.
Immunity
; 29(4): 602-14, 2008 Oct 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-18835197
13.
Blocking KV1.3 channels inhibits Th2 lymphocyte function and treats a rat model of asthma.
J Biol Chem
; 289(18): 12623-32, 2014 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-24644290
14.
Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases.
FASEB J
; 28(9): 3952-64, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24891519
15.
Development of highly selective Kv1.3-blocking peptides based on the sea anemone peptide ShK.
Mar Drugs
; 13(1): 529-42, 2015 Jan 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-25603346
16.
Total synthesis of human hepcidin through regioselective disulfide-bond formation by using the safety-catch cysteine protecting group 4,4'-dimethylsulfinylbenzhydryl.
Angew Chem Int Ed Engl
; 53(11): 2931-4, 2014 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24604812
17.
Adeno-Associated virus 8 delivers an immunomodulatory peptide to mouse liver more efficiently than to rat liver.
PLoS One
; 18(4): e0283996, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37040361
18.
Durable pharmacological responses from the peptide ShK-186, a specific Kv1.3 channel inhibitor that suppresses T cell mediators of autoimmune disease.
J Pharmacol Exp Ther
; 342(3): 642-53, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22637724
19.
A Conjugate between Lqh-8/6, a Natural Peptide Analogue of Chlorotoxin, and Doxorubicin Efficiently Induces Glioma Cell Death.
Biomedicines
; 10(10)2022 Oct 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36289865
20.
Computational design of peptides to target NaV1.7 channel with high potency and selectivity for the treatment of pain.
Elife
; 112022 12 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36576241