Detalhe da pesquisa
1.
Out-of-register ß-sheets suggest a pathway to toxic amyloid aggregates.
Proc Natl Acad Sci U S A
; 109(51): 20913-8, 2012 Dec 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-23213214
2.
Intracellular amyloid and the neuronal origin of Alzheimer neuritic plaques.
Neurobiol Dis
; 71: 53-61, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25092575
3.
A causative link between the structure of aberrant protein oligomers and their toxicity.
Nat Chem Biol
; 6(2): 140-7, 2010 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-20081829
4.
Intracellular Injection of Brain Extracts from Alzheimer's Disease Patients Triggers Unregulated Ca2+ Release from Intracellular Stores That Hinders Cellular Bioenergetics.
Cells
; 11(22)2022 11 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36429057
5.
Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of Aß in neurons, yielding senile plaques.
Nat Neurosci
; 25(6): 688-701, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35654956
6.
Preclinical and randomized clinical evaluation of the p38α kinase inhibitor neflamapimod for basal forebrain cholinergic degeneration.
Nat Commun
; 13(1): 5308, 2022 09 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36130946
7.
Assessing Rab5 Activation in Health and Disease.
Methods Mol Biol
; 2293: 273-294, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34453725
8.
A protective role for lipid raft cholesterol against amyloid-induced membrane damage in human neuroblastoma cells.
Biochim Biophys Acta
; 1788(10): 2204-16, 2009 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-19651105
9.
Generation of reactive oxygen species by beta amyloid fibrils and oligomers involves different intra/extracellular pathways.
Amino Acids
; 38(4): 1101-6, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19582548
10.
Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease.
Cell Rep
; 33(8): 108420, 2020 11 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-33238112
11.
Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction.
Neurobiol Dis
; 35(3): 352-8, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19523517
12.
Replicating neuroblastoma cells in different cell cycle phases display different vulnerability to amyloid toxicity.
J Mol Med (Berl)
; 86(2): 197-209, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17885746
13.
Transgenic expression of a ratiometric autophagy probe specifically in neurons enables the interrogation of brain autophagy in vivo.
Autophagy
; 15(3): 543-557, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30269645
14.
Curcumin protects cardiac cells against ischemia-reperfusion injury: effects on oxidative stress, NF-kappaB, and JNK pathways.
Free Radic Biol Med
; 45(6): 839-46, 2008 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18638545
15.
Protective effect of new S-acylglutathione derivatives against amyloid-induced oxidative stress.
Free Radic Biol Med
; 44(8): 1624-36, 2008 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18294463
16.
Differentiation increases the resistance of neuronal cells to amyloid toxicity.
Neurochem Res
; 33(12): 2516-31, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-18307032
17.
Dysfunction of autophagy and endosomal-lysosomal pathways: Roles in pathogenesis of Down syndrome and Alzheimer's Disease.
Free Radic Biol Med
; 114: 40-51, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28988799
18.
Differing molecular mechanisms appear to underlie early toxicity of prefibrillar HypF-N aggregates to different cell types.
FEBS J
; 273(10): 2206-22, 2006 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-16649997
19.
Protein misfolding, congophilia, oligomerization, and defective amyloid processing in preeclampsia.
Sci Transl Med
; 6(245): 245ra92, 2014 Jul 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-25031267
20.
Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice.
Mol Neurodegener
; 7: 37, 2012 Aug 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-22866920