Detalhe da pesquisa
1.
Fungicide-Resistant Botrytis in Forest Nurseries May Impact Disease Control in Norway Spruce.
Plant Dis
; 108(1): 139-148, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-37578357
2.
Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing.
J Am Chem Soc
; 142(19): 8706-8727, 2020 05 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32364710
3.
Synthesis of Pyridopyrazine-1,6-dione γ-Secretase Modulators via Selective 4-Methylimidazole N1-Buchwald Arylation.
J Org Chem
; 84(8): 4921-4925, 2019 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30620601
4.
Discovery of indole-derived pyridopyrazine-1,6-dione γ-secretase modulators that target presenilin.
Bioorg Med Chem Lett
; 25(4): 908-13, 2015 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25582600
5.
γ-Secretase modulator (GSM) photoaffinity probes reveal distinct allosteric binding sites on presenilin.
J Biol Chem
; 288(14): 9710-9720, 2013 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-23396974
6.
Enantioselective total syntheses of citrinadins A and B. Stereochemical revision of their assigned structures.
J Am Chem Soc
; 136(40): 14184-92, 2014 Oct 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-25211501
7.
Discovery of Clinical Candidate PF-06648671: A Potent γ-Secretase Modulator for the Treatment of Alzheimer's Disease.
J Med Chem
; 2024 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38848667
8.
Cerebrospinal fluid amyloid-ß (Aß) as an effect biomarker for brain Aß lowering verified by quantitative preclinical analyses.
J Pharmacol Exp Ther
; 342(2): 366-75, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22562771
9.
Development of clickable active site-directed photoaffinity probes for γ-secretase.
Bioorg Med Chem Lett
; 22(8): 2997-3000, 2012 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22418280
10.
Design and synthesis of dihydrobenzofuran amides as orally bioavailable, centrally active γ-secretase modulators.
Bioorg Med Chem Lett
; 22(8): 2906-11, 2012 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22429469
11.
Design, synthesis, and pharmacological evaluation of azetedine and pyrrolidine derivatives as dual norepinephrine reuptake inhibitors and 5-HT(1A) partial agonists.
Bioorg Med Chem Lett
; 21(2): 865-8, 2011 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21185183
12.
Photoaffinity Labeling and Quantitative Chemical Proteomics Identify LXRß as the Functional Target of Enhancers of Astrocytic apoE.
Cell Chem Biol
; 28(2): 148-157.e7, 2021 02 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-32997975
13.
Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19.
Nat Commun
; 12(1): 6055, 2021 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34663813
14.
Discovery of a Novel Inhibitor of Coronavirus 3CL Protease for the Potential Treatment of COVID-19.
bioRxiv
; 2021 Feb 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32935104
15.
An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19.
Science
; 374(6575): 1586-1593, 2021 Dec 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34726479
16.
Class I HDAC inhibition is a novel pathway for regulating astrocytic apoE secretion.
PLoS One
; 13(3): e0194661, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29579087
17.
Concise, stereoselective approach to the spirooxindole ring system of citrinadin A.
Org Lett
; 9(22): 4623-6, 2007 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-17918954
18.
Trifluoromethyl Oxetanes: Synthesis and Evaluation as a tert-Butyl Isostere.
ChemMedChem
; 12(19): 1574-1577, 2017 10 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28815966
19.
Structural and Chemical Biology of Presenilin Complexes.
Cold Spring Harb Perspect Med
; 7(12)2017 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28320827
20.
Discovery of cyclopropyl chromane-derived pyridopyrazine-1,6-dione γ-secretase modulators with robust central efficacy.
Medchemcomm
; 8(4): 730-743, 2017 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30108792