Detalhe da pesquisa
1.
Discovery of imidazopyridazines as potent Pim-1/2 kinase inhibitors.
Bioorg Med Chem Lett
; 26(22): 5580-5590, 2016 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27769621
2.
The discovery and optimization of aminooxadiazoles as potent Pim kinase inhibitors.
Bioorg Med Chem Lett
; 25(4): 847-55, 2015 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25599837
3.
Phosphoinositide-3-kinase inhibitors: evaluation of substituted alcohols as replacements for the piperazine sulfonamide portion of AMG 511.
Bioorg Med Chem Lett
; 24(24): 5630-5634, 2014 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25466188
4.
Identification of triazolopyridazinones as potent p38α inhibitors.
Bioorg Med Chem Lett
; 22(2): 1226-9, 2012 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22196117
5.
Synthesis and structure-activity relationships of dual PI3K/mTOR inhibitors based on a 4-amino-6-methyl-1,3,5-triazine sulfonamide scaffold.
Bioorg Med Chem Lett
; 22(17): 5714-20, 2012 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22832322
6.
Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe.
J Med Chem
; 65(6): 4972-4990, 2022 03 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35286090
7.
Part 2: Structure-activity relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38alpha mitogen-activated protein kinase.
Bioorg Med Chem Lett
; 20(5): 1680-4, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20138761
8.
Discovery of AM-6494: A Potent and Orally Efficacious ß-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor with in Vivo Selectivity over BACE2.
J Med Chem
; 63(5): 2263-2281, 2020 03 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31589043
9.
Part 1: Structure-Activity Relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38alpha mitogen-activated protein kinase.
Bioorg Med Chem Lett
; 19(16): 4724-8, 2009 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19574047
10.
Discovery of ( R)-8-(6-Methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4- b]pyrrol-2-yl)-3-(1-methylcyclopropyl)-2-((1-methylcyclopropyl)amino)quinazolin-4(3 H)-one, a Potent and Selective Pim-1/2 Kinase Inhibitor for Hematological Malignancies.
J Med Chem
; 62(3): 1523-1540, 2019 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30624936
11.
Trisubstituted pyrimidines as transient receptor potential vanilloid 1 (TRPV1) antagonists with improved solubility.
Bioorg Med Chem Lett
; 17(23): 6539-45, 2007 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17937985
12.
Discovery and Optimization of Macrocyclic Quinoxaline-pyrrolo-dihydropiperidinones as Potent Pim-1/2 Kinase Inhibitors.
ACS Med Chem Lett
; 7(4): 408-12, 2016 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27096050
13.
Discovery and Optimization of Quinazolinone-pyrrolopyrrolones as Potent and Orally Bioavailable Pan-Pim Kinase Inhibitors.
J Med Chem
; 59(13): 6407-30, 2016 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27285051
14.
Discovery and in vivo evaluation of (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and related PI3Kδ inhibitors for inflammation and autoimmune disease.
J Med Chem
; 58(1): 480-511, 2015 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-25469863
15.
Oxopyrido[2,3-d]pyrimidines as Covalent L858R/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors.
ACS Med Chem Lett
; 6(9): 987-92, 2015 Sep 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26396685
16.
Structure-based design of a novel series of potent, selective inhibitors of the class I phosphatidylinositol 3-kinases.
J Med Chem
; 55(11): 5188-219, 2012 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-22548365
17.
Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.
J Med Chem
; 55(17): 7796-816, 2012 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-22897589
18.
Discovery and evaluation of 7-alkyl-1,5-bis-aryl-pyrazolopyridinones as highly potent, selective, and orally efficacious inhibitors of p38alpha mitogen-activated protein kinase.
J Med Chem
; 53(7): 2973-85, 2010 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-20218619
19.
Small molecule p38 MAP kinase inhibitors for the treatment of inflammatory diseases: novel structures and developments during 2006-2008.
Curr Top Med Chem
; 8(16): 1452-67, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18991731
20.
3-amino-7-phthalazinylbenzoisoxazoles as a novel class of potent, selective, and orally available inhibitors of p38alpha mitogen-activated protein kinase.
J Med Chem
; 51(20): 6280-92, 2008 Oct 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-18817364