Detalhe da pesquisa
1.
Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia.
Nature
; 593(7860): 597-601, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33902106
2.
Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature
; 510(7505): 422-426, 2014 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-24814345
3.
Hydrophobicity of protein determinants influences the recognition of substrates by EDEM1 and EDEM2 in human cells.
BMC Cell Biol
; 16: 1, 2015 Feb 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-25655076
4.
Insight into S-adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits.
Biochem J
; 452(1): 27-36, 2013 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23425511
5.
Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.
Nature
; 448(7149): 87-91, 2007 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-17589501
6.
Inhibition of METTL3 Results in a Cell-Intrinsic Interferon Response That Enhances Antitumor Immunity.
Cancer Discov
; 13(10): 2228-2247, 2023 10 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37548590
7.
Crystal structure of the secretory isozyme of mammalian carbonic anhydrases CA VI: implications for biological assembly and inhibitor development.
Biochem Biophys Res Commun
; 419(3): 485-9, 2012 Mar 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-22366092
8.
Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family.
BMC Struct Biol
; 12: 14, 2012 Jun 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22720794
9.
Therapeutic Potential of Targeting Plasminogen Activator Inhibitor-1 in COVID-19.
Trends Pharmacol Sci
; 42(6): 431-433, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33867130
10.
Small-molecule modulators of serine protease inhibitor proteins (serpins).
Drug Discov Today
; 26(2): 442-454, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33259801
11.
Discovery of a potent and selective inhibitor for human carbonyl reductase 1 from propionate scanning applied to the macrolide zearalenone.
Bioorg Med Chem
; 17(2): 530-6, 2009 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19097799
12.
Structural insight into binding of Staphylococcus aureus to human fibronectin.
FEBS Lett
; 580(1): 273-7, 2006 Jan 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-16376343
13.
Structural definitions of Jumonji family demethylase selectivity.
Drug Discov Today
; 20(6): 743-9, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25555749
14.
Structural and biochemical studies of a moderately thermophilic exonuclease I from Methylocaldum szegediense.
PLoS One
; 10(2): e0117470, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25658953
15.
The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants.
Bone
; 81: 478-486, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26318908
16.
Crystal structure of human carbonic anhydrase-related protein VIII reveals the basis for catalytic silencing.
Proteins
; 76(2): 507-11, 2009 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19360879
17.
Crystal structures of malonyl-coenzyme A decarboxylase provide insights into its catalytic mechanism and disease-causing mutations.
Structure
; 21(7): 1182-92, 2013 Jul 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-23791943
18.
High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships.
PLoS One
; 5(11): e13719, 2010 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-21072165
19.
Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A.
J Mol Biol
; 388(5): 997-1008, 2009 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-19345228
20.
Analysis of the substrate-binding site of human carbonyl reductases CBR1 and CBR3 by site-directed mutagenesis.
Chem Biol Interact
; 178(1-3): 234-41, 2009 Mar 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-19061875