Detalhe da pesquisa
1.
6-Azaspiro[2.5]octanes as small molecule agonists of the human glucagon-like peptide-1 receptor.
Bioorg Med Chem Lett
; 94: 129454, 2023 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37591316
2.
Small molecule inhibitors of PCSK9. SAR investigations of head and amine groups.
Bioorg Med Chem Lett
; 92: 129394, 2023 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37379958
3.
Positive allosteric modulators of the α7 nicotinic acetylcholine receptor: SAR investigation around PNU-120596.
Bioorg Med Chem Lett
; 93: 129433, 2023 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37557923
4.
Correction: Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain.
PLoS Biol
; 16(4): e1002628, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29664898
5.
Acylative Dynamic Kinetic Resolution of Secondary Alcohols: Tandem Catalysis by HyperBTM and Bäckvall's Ruthenium Complex.
J Org Chem
; 86(10): 7189-7202, 2021 05 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33974415
6.
Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain.
PLoS Biol
; 15(3): e2001882, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28323820
7.
Cycloisomerization of Olefins in Water.
Angew Chem Int Ed Engl
; 59(31): 12998-13003, 2020 07 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-32285542
8.
RASS-Enabled S/P-C and S-N Bond Formation for DEL Synthesis.
Angew Chem Int Ed Engl
; 59(19): 7377-7383, 2020 05 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32050046
9.
Expanding Reactivity in DNA-Encoded Library Synthesis via Reversible Binding of DNA to an Inert Quaternary Ammonium Support.
J Am Chem Soc
; 141(25): 9998-10006, 2019 06 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-31136164
10.
Discovery of N-(piperidin-3-yl)-N-(pyridin-2-yl)piperidine/piperazine-1-carboxamides as small molecule inhibitors of PCSK9.
Bioorg Med Chem Lett
; 28(23-24): 3685-3688, 2018 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30482620
11.
Development of a Chiral DMAP Catalyst for the Dynamic Kinetic Resolution of Azole Hemiaminals.
J Org Chem
; 82(2): 869-886, 2017 01 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28060519
12.
Liver-Targeted Small-Molecule Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9 Synthesis.
Angew Chem Int Ed Engl
; 56(51): 16218-16222, 2017 12 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-29073340
13.
Regio- and Enantioselective Synthesis of Azole Hemiaminal Esters by Lewis Base Catalyzed Dynamic Kinetic Resolution.
J Am Chem Soc
; 138(14): 4818-23, 2016 Apr 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-27003237
14.
PF-07059013: A non-covalent hemoglobin modulator favorably impacts disease state in a mouse model of sickle cell disease.
Am J Hematol
; 96(8): E272-E275, 2021 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33891711
15.
Design and synthesis of aryl sulfonamide-based nonsteroidal mineralocorticoid receptor antagonists.
Bioorg Med Chem Lett
; 23(23): 6239-42, 2013 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24157365
16.
Discovery of 5-phenoxy-1,3-dimethyl-1H-pyrazole-4-carboxamides as potent agonists of TGR5 via sequential combinatorial libraries.
Bioorg Med Chem Lett
; 23(5): 1407-11, 2013 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23337601
17.
Regioselective hydroarylations and parallel kinetic resolution of Vince lactam.
Angew Chem Int Ed Engl
; 52(40): 10607-10, 2013 Sep 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-23956102
18.
Metabolism, excretion, and pharmacokinetics of ((3,3-difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone, a dipeptidyl peptidase inhibitor, in rat, dog and human.
Drug Metab Dispos
; 40(11): 2143-61, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22896728
19.
A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor.
J Med Chem
; 65(12): 8208-8226, 2022 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35647711
20.
The use of plasma aldosterone and urinary sodium to potassium ratio as translatable quantitative biomarkers of mineralocorticoid receptor antagonism.
J Transl Med
; 9: 180, 2011 Oct 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22017794