Detalhe da pesquisa
1.
Agonistic Human Antibodies Binding to Lecithin-Cholesterol Acyltransferase Modulate High Density Lipoprotein Metabolism.
J Biol Chem
; 291(6): 2799-811, 2016 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26644477
2.
BacMam production of active recombinant lecithin-cholesterol acyltransferase: Expression, purification and characterization.
Protein Expr Purif
; 125: 1-6, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-26363122
3.
The high-resolution crystal structure of human LCAT.
J Lipid Res
; 56(9): 1711-9, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26195816
4.
Anti-PCSK9 antibody pharmacokinetics and low-density lipoprotein-cholesterol pharmacodynamics in nonhuman primates are antigen affinity-dependent and exhibit limited sensitivity to neonatal Fc receptor-binding enhancement.
J Pharmacol Exp Ther
; 353(1): 119-31, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25653417
5.
Discovery and optimization of a series of liver X receptor antagonists.
Bioorg Med Chem Lett
; 22(18): 5966-70, 2012 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22901900
6.
Discovery of a new binding mode for a series of liver X receptor agonists.
Bioorg Med Chem Lett
; 22(7): 2407-10, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22406115
7.
A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates.
Proc Natl Acad Sci U S A
; 106(24): 9820-5, 2009 Jun 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-19443683
8.
Discovery of Selective Pituitary Adenylate Cyclase 1 Receptor (PAC1R) Antagonist Peptides Potent in a Maxadilan/PACAP38-Induced Increase in Blood Flow Pharmacodynamic Model.
J Med Chem
; 64(6): 3427-3438, 2021 03 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33715378
9.
The crystal structure of PCSK9: a regulator of plasma LDL-cholesterol.
Structure
; 15(5): 545-52, 2007 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-17502100
10.
Novel inhibitors of hepatitis C virus RNA-dependent RNA polymerases.
J Mol Biol
; 357(4): 1051-7, 2006 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-16476448
11.
SAR and mode of action of novel non-nucleoside inhibitors of hepatitis C NS5b RNA polymerase.
J Med Chem
; 49(3): 1034-46, 2006 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-16451069
12.
Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers.
Biochem J
; 390(Pt 1): 125-36, 2005 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15839837
13.
Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3.
J Med Chem
; 57(8): 3430-49, 2014 Apr 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-24641103
14.
Molecular basis of PCSK9 function.
Atherosclerosis
; 203(1): 1-7, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-18649882