Detalhe da pesquisa
1.
The T-cell fingerprint of MALT1 paracaspase revealed by selective inhibition.
Immunol Cell Biol
; 96(1): 81-99, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29359407
2.
N-aryl-piperidine-4-carboxamides as a novel class of potent inhibitors of MALT1 proteolytic activity.
Bioorg Med Chem Lett
; 28(12): 2153-2158, 2018 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29759726
3.
Discovery of New Binders for DCAF1, an Emerging Ligase Target in the Targeted Protein Degradation Field.
ACS Med Chem Lett
; 14(7): 949-954, 2023 Jul 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37465299
4.
Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies.
J Med Chem
; 65(7): 5317-5333, 2022 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35352560
5.
Design of two new chemotypes for inhibiting the Janus kinase 2 by scaffold morphing.
Bioorg Med Chem Lett
; 20(6): 1858-60, 2010 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20172718
6.
2-Amino-aryl-7-aryl-benzoxazoles as potent, selective and orally available JAK2 inhibitors.
Bioorg Med Chem Lett
; 20(5): 1724-7, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20138510
7.
Discovery and SAR of potent, orally available 2,8-diaryl-quinoxalines as a new class of JAK2 inhibitors.
Bioorg Med Chem Lett
; 20(8): 2609-13, 2010 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20231096
8.
Optimization of the In Vivo Potency of Pyrazolopyrimidine MALT1 Protease Inhibitors by Reducing Metabolism and Increasing Potency in Whole Blood.
J Med Chem
; 63(23): 14594-14608, 2020 12 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33216547
9.
Discovery of Potent, Highly Selective, and In Vivo Efficacious, Allosteric MALT1 Inhibitors by Iterative Scaffold Morphing.
J Med Chem
; 63(23): 14576-14593, 2020 12 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33252239
10.
Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors.
J Med Chem
; 58(16): 6348-58, 2015 Aug 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-26181851
11.
Modulation of activation-loop phosphorylation by JAK inhibitors is binding mode dependent.
Cancer Discov
; 2(6): 512-523, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22684457
12.
Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805.
Mol Cancer Ther
; 9(7): 1945-55, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20587663
13.
A short and concise asymmetric synthesis of hamigeran B.
Chemistry
; 11(3): 951-9, 2005 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-15612053
14.
An asymmetric synthesis of hamigeran B via a Pd asymmetric allylic alkylation for enantiodiscrimination.
J Am Chem Soc
; 126(14): 4480-1, 2004 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-15070341