Detalhe da pesquisa
1.
Targeting pleckstrin-2/Akt signaling reduces proliferation in myeloproliferative neoplasm models.
J Clin Invest
; 133(6)2023 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36719747
2.
Novel substituted pyrimidines as HCV replication (replicase) inhibitors.
Bioorg Med Chem Lett
; 22(2): 1160-4, 2012 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22178556
3.
Discovery of oxazole-based PDE4 inhibitors with picomolar potency.
Bioorg Med Chem Lett
; 22(7): 2594-7, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22401864
4.
Pyridofuran substituted pyrimidine derivatives as HCV replication (replicase) inhibitors.
Bioorg Med Chem Lett
; 22(15): 5144-9, 2012 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22814211
5.
5-Benzothiazole substituted pyrimidine derivatives as HCV replication (replicase) inhibitors.
Bioorg Med Chem Lett
; 22(9): 3229-34, 2012 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22472692
6.
Synthesis and SAR of pyridothiazole substituted pyrimidine derived HCV replication inhibitors.
Bioorg Med Chem Lett
; 22(17): 5652-7, 2012 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22858143
7.
2-(2-Aminothiazol-4-yl)pyrrolidine-based tartrate diamides as potent, selective and orally bioavailable TACE inhibitors.
Bioorg Med Chem Lett
; 21(10): 3172-6, 2011 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21458257
8.
Novel TNF-α converting enzyme (TACE) inhibitors as potential treatment for inflammatory diseases.
Bioorg Med Chem Lett
; 20(24): 7283-7, 2010 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21106451
9.
Structure and activity relationships of tartrate-based TACE inhibitors.
Bioorg Med Chem Lett
; 20(16): 4812-5, 2010 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20638281
10.
Biaryl substituted hydantoin compounds as TACE inhibitors.
Bioorg Med Chem Lett
; 20(17): 5286-9, 2010 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20663669
11.
The discovery of novel tartrate-based TNF-alpha converting enzyme (TACE) inhibitors.
Bioorg Med Chem Lett
; 20(3): 1189-93, 2010 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20022498
12.
Discovery and SAR of hydantoin TACE inhibitors.
Bioorg Med Chem Lett
; 20(6): 1877-80, 2010 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20172725
13.
Challenges in modern drug discovery: a case study of boceprevir, an HCV protease inhibitor for the treatment of hepatitis C virus infection.
Acc Chem Res
; 41(1): 50-9, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18193821
14.
Structural characterization of in vitro rat liver microsomal metabolites of antihistamine desloratadine using LTQ-Orbitrap hybrid mass spectrometer in combination with online hydrogen/deuterium exchange HR-LC/MS.
J Mass Spectrom
; 44(2): 203-13, 2009 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18853472
15.
Structural determinants for histamine H(1) affinity, hERG affinity and QTc prolongation in a series of terfenadine analogs.
Bioorg Med Chem Lett
; 19(17): 5043-7, 2009 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19660947
16.
A useful Pd-catalyzed Negishi coupling approach to benzylic sulfonamide derivatives.
Org Lett
; 10(12): 2517-20, 2008 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-18491861
17.
Benzimidazole-substituted (3-phenoxypropyl)amines as histamine H3 receptor ligands.
Bioorg Med Chem Lett
; 18(18): 5032-6, 2008 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18752952
18.
Asymmetric synthesis of 4,4-disubstituted-2-imidazoli-dinones: potent NK1 antagonists.
Org Lett
; 5(23): 4249-51, 2003 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-14601972
19.
Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor.
ACS Med Chem Lett
; 1(2): 64-9, 2010 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900178
20.
Discovery of a highly potent series of oxazole-based phosphodiesterase 4 inhibitors.
Bioorg Med Chem Lett
; 17(18): 5150-4, 2007 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17683932