Detalhe da pesquisa
1.
Species comparison of compounds with known blood pressure effects in a vascular smooth muscle cell collagen contraction assay.
J Pharmacol Toxicol Methods
; 123: 107290, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37442214
2.
Suppression of superoxide/hydrogen peroxide production at mitochondrial site IQ decreases fat accumulation, improves glucose tolerance and normalizes fasting insulin concentration in mice fed a high-fat diet.
Free Radic Biol Med
; 204: 276-286, 2023 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37217089
3.
Pharmacological properties and procognitive effects of ABT-288, a potent and selective histamine H3 receptor antagonist.
J Pharmacol Exp Ther
; 343(1): 233-45, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22815533
4.
Thienopyridine ureas as dual inhibitors of the VEGF and Aurora kinase families.
Bioorg Med Chem Lett
; 22(9): 3208-12, 2012 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22465635
5.
Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins.
J Pharmacol Toxicol Methods
; 109: 107066, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33838254
6.
Automated Blood Sampling in a Canine Telemetry Cardiovascular Model.
Comp Med
; 71(2): 133-140, 2021 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33814031
7.
Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins.
J Pharmacol Toxicol Methods
; 111: 107109, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34416395
8.
Automated blood sampling in canine telemetry model: Enhanced assessment of immune liabilities.
J Pharmacol Toxicol Methods
; 112: 107115, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34403748
9.
Tumour-selective antivascular effects of the novel anti-mitotic compound A-318315: An in vivo rat regional haemodynamic study.
Clin Exp Pharmacol Physiol
; 37(5-6): 636-40, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20132238
10.
Drug-induced QT prolongation: Concordance of preclinical anesthetized canine model in relation to published clinical observations for ten CiPA drugs.
J Pharmacol Toxicol Methods
; 103: 106871, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32360993
11.
Cardiovascular effects of torcetrapib in conscious and pentobarbital-anesthetized dogs.
J Cardiovasc Pharmacol
; 54(6): 543-51, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19770671
12.
Evoked changes in cardiovascular function in rats by infusion of levosimendan, OR-1896 [(R)-N-(4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)acetamide], OR-1855 [(R)-6-(4-aminophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one], dobutamine, and milrinone: comparative effects on peripheral resistance, cardiac output, dP/dt, pulse rate, and blood pressure.
J Pharmacol Exp Ther
; 325(1): 331-40, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18171907
13.
Tetrahydropyridine-4-carboxamides as novel, potent transient receptor potential vanilloid 1 (TRPV1) antagonists.
Bioorg Med Chem
; 16(18): 8516-25, 2008 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18722778
14.
The evaluation of drug-induced changes in left ventricular function in pentobarbital-anesthetized dogs.
J Pharmacol Toxicol Methods
; 91: 27-35, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29330133
15.
Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension.
J Med Chem
; 50(13): 2990-3003, 2007 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-17523610
16.
Predictive, non-GLP models of secondary pharmacodynamics: putting the best compounds forward.
Curr Opin Chem Biol
; 9(4): 392-9, 2005 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-15950522
17.
Screening for cardiovascular safety: a structure-activity approach for guiding lead selection of melanin concentrating hormone receptor 1 antagonists.
J Med Chem
; 49(7): 2339-52, 2006 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-16570930
18.
Optimization of chromone-2-carboxamide melanin concentrating hormone receptor 1 antagonists: assessment of potency, efficacy, and cardiovascular safety.
J Med Chem
; 49(22): 6569-84, 2006 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-17064075
19.
Discovery of 2-[4-{{2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279): a very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes.
J Med Chem
; 49(21): 6416-20, 2006 Oct 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-17034148
20.
Simultaneous measurement of arterial and left ventricular pressure in conscious freely moving rats by telemetry.
J Pharmacol Toxicol Methods
; 79: 23-33, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26778372