Detalhe da pesquisa
1.
Universal Affinity Capture Liquid Chromatography-Mass Spectrometry Assay for Evaluation of Biotransformation of Site-Specific Antibody Drug Conjugates in Preclinical Studies.
Anal Chem
; 92(2): 2065-2073, 2020 01 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31860282
2.
Design, synthesis and biological evaluation of phenol-linked uncialamycin antibody-drug conjugates.
Bioorg Med Chem Lett
; 30(1): 126782, 2020 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31767265
3.
Streamlined Total Synthesis of Uncialamycin and Its Application to the Synthesis of Designed Analogues for Biological Investigations.
J Am Chem Soc
; 138(26): 8235-46, 2016 07 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27266267
4.
Total synthesis of dihydrolysergic acid and dihydrolysergol: development of a divergent synthetic strategy applicable to rapid assembly of D-ring analogs.
Tetrahedron
; 71(35): 5897-5905, 2015 Sep 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-26273113
5.
Synthesis of a des-B-ring bryostatin analogue leads to an unexpected ring expansion of the bryolactone core.
J Am Chem Soc
; 136(38): 13202-8, 2014 Sep 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-25207434
6.
Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology.
ACS Med Chem Lett
; 15(2): 189-196, 2024 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38352849
7.
Discovery of Novel TLR7 Agonists as Systemic Agent for Combination With aPD1 for Use in Immuno-oncology.
ACS Med Chem Lett
; 15(2): 181-188, 2024 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38352830
8.
A Pd(0)-mediated indole (macro)cyclization reaction.
J Am Chem Soc
; 135(4): 1600-6, 2013 Jan 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-23298368
9.
Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity.
Bioorg Med Chem Lett
; 22(12): 4084-8, 2012 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22579485
10.
Total synthesis of bryostatin 1.
J Am Chem Soc
; 133(4): 744-7, 2011 Feb 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-21175177
11.
Chemical Modification of Linkers Provides Stable Linker-Payloads for the Generation of Antibody-Drug Conjugates.
ACS Med Chem Lett
; 11(11): 2190-2194, 2020 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33214828
12.
Synthetic Studies Toward Bryostatin 1: Preparation of a C(1)-C(16) Fragment by Pyran Annulation.
Tetrahedron Lett
; 47(47): 8267-8270, 2006 Nov 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-17404602
13.
Molecular modeling, total synthesis, and biological evaluations of C9-deoxy bryostatin 1.
Angew Chem Int Ed Engl
; 49(27): 4580-4, 2010 Jun 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-20491108
14.
Biological profile of the less lipophilic and synthetically more accessible bryostatin 7 closely resembles that of bryostatin 1.
ACS Chem Biol
; 8(4): 767-77, 2013 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-23369356
15.
Substitution on the A-ring confers to bryopyran analogues the unique biological activity characteristic of bryostatins and distinct from that of the phorbol esters.
Org Lett
; 11(3): 593-6, 2009 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-19113896