Detalhe da pesquisa
1.
Structure-based design of isoindoline-1,3-diones and 2,3-dihydrophthalazine-1,4-diones as novel B-Raf inhibitors.
Bioorg Med Chem Lett
; 21(23): 6941-4, 2011 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22024030
2.
Synthesis and biological evaluation of tricyclic anilinopyrimidines as IKKbeta inhibitors.
Bioorg Med Chem Lett
; 20(12): 3821-5, 2010 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20471256
3.
Discovery of highly potent and selective type I B-Raf kinase inhibitors.
Bioorg Med Chem Lett
; 19(23): 6571-4, 2009 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19854649
4.
Novel pyrazolopyrimidines as highly potent B-Raf inhibitors.
Bioorg Med Chem Lett
; 19(24): 6957-61, 2009 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19875283
5.
Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors.
Bioorg Med Chem Lett
; 19(23): 6519-23, 2009 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19864136
6.
Synthesis, SAR study and biological evaluation of novel pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as anti-proliferative agents.
Bioorg Med Chem
; 17(5): 2091-100, 2009 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19200741
7.
4-Anilino-7-alkenylquinoline-3-carbonitriles as potent MEK1 kinase inhibitors.
Bioorg Med Chem
; 16(20): 9202-11, 2008 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18815050
8.
Structure-Based Approach To Identify 5-[4-Hydroxyphenyl]pyrrole-2-carbonitrile Derivatives as Potent and Tissue Selective Androgen Receptor Modulators.
J Med Chem
; 60(14): 6451-6457, 2017 07 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-28696695
9.
4-Anilino-7,8-dialkoxybenzo[g]quinoline-3-carbonitriles as potent Src kinase inhibitors.
J Med Chem
; 48(19): 5909-20, 2005 Sep 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-16161995
10.
Identification of 4-anilino-3-quinolinecarbonitrile inhibitors of mitogen-activated protein/extracellular signal-regulated kinase 1 kinase.
Mol Cancer Ther
; 3(6): 755-62, 2004 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-15210862
11.
Constructing rigorous and broad biosurveillance networks for detecting emerging zoonotic outbreaks.
PLoS One
; 10(5): e0124037, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25946164
12.
1-(2-Hydroxy-2-methyl-3-phenoxypropanoyl)indoline-4-carbonitrile derivatives as potent and tissue selective androgen receptor modulators.
J Med Chem
; 57(6): 2462-71, 2014 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24527807
13.
An epidemiological model of spatial coupling for trips longer than the infectious period.
Math Biosci
; 242(1): 1-8, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23246512
14.
Indazolylpyrazolopyrimidine as highly potent B-Raf inhibitors with in vivo activity.
J Med Chem
; 53(21): 7874-8, 2010 Nov 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-20961062
15.
Dramatic effect of solvent hydrogen bond basicity on the regiochemistry of S(N)Ar reactions of electron-deficient polyfluoroarenes.
Org Lett
; 11(24): 5662-4, 2009 Dec 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-19911788
16.
Pyranonaphthoquinone lactones: a new class of AKT selective kinase inhibitors alkylate a regulatory loop cysteine.
J Med Chem
; 52(8): 2181-4, 2009 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-19309081
17.
IkappaBalpha kinase inhibitor IKI-1 conferred tumor necrosis factor alpha sensitivity to pancreatic cancer cells and a xenograft tumor model.
Cancer Res
; 68(22): 9519-24, 2008 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19010928
18.
Pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as novel antiproliferative agents: exploration of core and headpiece structure-activity relationships.
Bioorg Med Chem Lett
; 17(6): 1641-5, 2007 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17275298
19.
Identification of a novel class of selective Tpl2 kinase inhibitors: 4-Alkylamino-[1,7]naphthyridine-3-carbonitriles.
Bioorg Med Chem
; 15(19): 6425-42, 2007 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17664070
20.
7-(aryl/heteroaryl-2-ylethynyl)-4-phenylamino-3-quinolinecarbonitriles as new Src kinase inhibitors: addition of water solubilizing groups.
Bioorg Med Chem Lett
; 16(15): 3993-7, 2006 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16735116