Detalhe da pesquisa
1.
Unraveling ETC complex I function in ferroptosis reveals a potential ferroptosis-inducing therapeutic strategy for LKB1-deficient cancers.
Mol Cell
; 84(10): 1964-1979.e6, 2024 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38759628
2.
Spatial mapping of mitochondrial networks and bioenergetics in lung cancer.
Nature
; 615(7953): 712-719, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36922590
3.
DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer.
Nature
; 593(7860): 586-590, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33981038
4.
A ferroptosis defense mechanism mediated by glycerol-3-phosphate dehydrogenase 2 in mitochondria.
Proc Natl Acad Sci U S A
; 119(26): e2121987119, 2022 06 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35749365
5.
Targeting In Vivo Metabolic Vulnerabilities of Th2 and Th17 Cells Reduces Airway Inflammation.
J Immunol
; 206(6): 1127-1139, 2021 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33558372
6.
Functional antibody characterization via direct structural analysis and information-driven protein-protein docking.
Proteins
; 90(4): 919-935, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34773424
7.
Author Correction: DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer.
Nature
; 596(7873): E13, 2021 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-34341547
8.
Ribosomal protein S7 is both a regulator and a substrate of MDM2.
Mol Cell
; 35(3): 316-26, 2009 Aug 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-19683495
9.
Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism.
Proc Natl Acad Sci U S A
; 111(47): 16814-9, 2014 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-25385601
10.
Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression.
Proc Natl Acad Sci U S A
; 110(46): 18626-31, 2013 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24167278
11.
Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance.
Nat Commun
; 15(1): 79, 2024 01 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38167301
12.
Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species.
Proc Natl Acad Sci U S A
; 107(16): 7461-6, 2010 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-20351271
13.
SLC7A11 expression level dictates differential responses to oxidative stress in cancer cells.
Nat Commun
; 14(1): 3673, 2023 06 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37339981
14.
Hepatocyte CYR61 polarizes profibrotic macrophages to orchestrate NASH fibrosis.
Sci Transl Med
; 15(715): eade3157, 2023 09 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37756381
15.
Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis.
Nat Cell Biol
; 25(3): 404-414, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36747082
16.
Deconstructing nucleotide binding activity of the Mdm2 RING domain.
Nucleic Acids Res
; 38(21): 7587-98, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20671028
17.
A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers.
Nat Commun
; 13(1): 2206, 2022 04 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-35459868
18.
Inhibition of glucose transport synergizes with chemical or genetic disruption of mitochondrial metabolism and suppresses TCA cycle-deficient tumors.
Cell Chem Biol
; 29(3): 423-435.e10, 2022 03 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34715056
19.
KEAP1 deficiency drives glucose dependency and sensitizes lung cancer cells and tumors to GLUT inhibition.
iScience
; 24(6): 102649, 2021 Jun 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34151236
20.
Discovery and Optimization of Glucose Uptake Inhibitors.
J Med Chem
; 63(10): 5201-5211, 2020 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32282207