Detalhe da pesquisa
1.
Xanthopsin-Like Systems via Site-Specific Click-Functionalization of a Retinoic Acid Binding Protein.
Chembiochem
; 23(1): e202100449, 2022 01 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34647400
2.
Structural Characterization of Human Heat Shock Protein 90 N-Terminal Domain and Its Variants K112R and K112A in Complex with a Potent 1,2,3-Triazole-Based Inhibitor.
Int J Mol Sci
; 23(16)2022 Aug 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36012721
3.
Exploiting ELIOT for Scaffold-Repurposing Opportunities: TRIM33 a Possible Novel E3 Ligase to Expand the Toolbox for PROTAC Design.
Int J Mol Sci
; 23(22)2022 Nov 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36430693
4.
Iron Binding in the Ferroxidase Site of Human Mitochondrial Ferritin.
Chemistry
; 27(59): 14690-14701, 2021 Oct 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-34343376
5.
VNRX-5133 (Taniborbactam), a Broad-Spectrum Inhibitor of Serine- and Metallo-ß-Lactamases, Restores Activity of Cefepime in Enterobacterales and Pseudomonas aeruginosa.
Antimicrob Agents Chemother
; 64(3)2020 02 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31871094
6.
Iron Biomineral Growth from the Initial Nucleation Seed in L-Ferritin.
Chemistry
; 26(26): 5770-5773, 2020 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32027764
7.
Chemistry at the protein-mineral interface in L-ferritin assists the assembly of a functional (µ3-oxo)Tris[(µ2-peroxo)] triiron(III) cluster.
Proc Natl Acad Sci U S A
; 114(10): 2580-2585, 2017 03 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28202724
8.
Fibrils of α-Synuclein Abolish the Affinity of Cu2+-Binding Site to His50 and Induce Hopping of Cu2+ Ions in the Termini.
Inorg Chem
; 58(16): 10920-10927, 2019 Aug 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-31369243
9.
Structural and Functional Characterization of the Human Thymidylate Synthase (hTS) Interface Variant R175C, New Perspectives for the Development of hTS Inhibitors.
Molecules
; 24(7)2019 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30959951
10.
Targeting Methyltransferases in Human Pathogenic Bacteria: Insights into Thymidylate Synthase (TS) and Flavin-Dependent TS (FDTS).
Molecules
; 24(8)2019 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-31027295
11.
Structural Comparison of Enterococcus faecalis and Human Thymidylate Synthase Complexes with the Substrate dUMP and Its Analogue FdUMP Provides Hints about Enzyme Conformational Variabilities.
Molecules
; 24(7)2019 Mar 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-30935102
12.
The structure of the human glutaminyl cyclase-SEN177 complex indicates routes for developing new potent inhibitors as possible agents for the treatment of neurological disorders.
J Biol Inorg Chem
; 23(8): 1219-1226, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30132075
13.
In Silico Identification and In Vitro Evaluation of Natural Inhibitors of Leishmania major Pteridine Reductase I.
Molecules
; 22(12)2017 Dec 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29211037
14.
Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity.
Molecules
; 22(3)2017 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28282886
15.
Crystal Structure of the Pseudomonas aeruginosa BEL-1 Extended-Spectrum ß-Lactamase and Its Complexes with Moxalactam and Imipenem.
Antimicrob Agents Chemother
; 60(12): 7189-7199, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27671060
16.
Ferroxidase Activity in Eukaryotic Ferritin is Controlled by Accessory-Iron-Binding Sites in the Catalytic Cavity.
Chemistry
; 22(45): 16213-16219, 2016 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27650996
17.
Iron binding to human heavy-chain ferritin.
Acta Crystallogr D Biol Crystallogr
; 71(Pt 9): 1909-20, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26327381
18.
Time-lapse anomalous X-ray diffraction shows how Fe(2+) substrate ions move through ferritin protein nanocages to oxidoreductase sites.
Acta Crystallogr D Biol Crystallogr
; 71(Pt 4): 941-53, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25849404
19.
Evolution to carbapenem-hydrolyzing activity in noncarbapenemase class D ß-lactamase OXA-10 by rational protein design.
Proc Natl Acad Sci U S A
; 108(45): 18424-9, 2011 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22042844
20.
Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase.
Proc Natl Acad Sci U S A
; 108(34): E542-9, 2011 Aug 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-21795601