Detalhe da pesquisa
1.
Brominated oxime nucleophiles are efficiently reactivating cholinesterases inhibited by nerve agents.
Arch Toxicol
; 2024 May 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-38789714
2.
Structure-Guided Design of N-Methylpropargylamino-Quinazoline Derivatives as Multipotent Agents for the Treatment of Alzheimer's Disease.
Int J Mol Sci
; 24(11)2023 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37298087
3.
Charged pyridinium oximes with thiocarboxamide moiety are equally or less effective reactivators of organophosphate-inhibited cholinesterases compared to analogous carboxamides.
J Enzyme Inhib Med Chem
; 37(1): 760-767, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-35193448
4.
Sertraline as a new potential anthelmintic against Haemonchus contortus: toxicity, efficacy, and biotransformation.
Vet Res
; 52(1): 143, 2021 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34895342
5.
Huprine Y - Tryptophan heterodimers with potential implication to Alzheimer's disease treatment.
Bioorg Med Chem Lett
; 43: 128100, 2021 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33984470
6.
Derivatives of montanine-type alkaloids and their implication for the treatment of Alzheimer's disease: Synthesis, biological activity and in silico study.
Bioorg Med Chem Lett
; 51: 128374, 2021 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34555506
7.
Development of versatile and potent monoquaternary reactivators of acetylcholinesterase.
Arch Toxicol
; 95(3): 985-1001, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33517499
8.
The Impact of Dextran Sodium Sulfate-Induced Gastrointestinal Injury on the Pharmacokinetic Parameters of Donepezil and Its Active Metabolite 6-O-desmethyldonepezil, and Gastric Myoelectric Activity in Experimental Pigs.
Molecules
; 26(8)2021 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33918638
9.
From orexin receptor agonist YNT-185 to novel antagonists with drug-like properties for the treatment of insomnia.
Bioorg Chem
; 103: 104179, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32891860
10.
Benzothiazolyl Ureas are Low Micromolar and Uncompetitive Inhibitors of 17ß-HSD10 with Implications to Alzheimer's Disease Treatment.
Int J Mol Sci
; 21(6)2020 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32192199
11.
Wide-Antimicrobial Spectrum of Picolinium Salts.
Molecules
; 25(9)2020 May 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32403238
12.
Substituted Piperazines as Novel Potential Radioprotective Agents.
Molecules
; 25(3)2020 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-31991816
13.
Novel quinazolin-4-one derivatives as potentiating agents of doxorubicin cytotoxicity.
Bioorg Chem
; 82: 204-210, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30326402
14.
Metabolism of drugs and other xenobiotics in giant liver fluke (Fascioloides magna).
Xenobiotica
; 46(2): 132-40, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26153440
15.
Biotransformation of anthelmintics and the activity of drug-metabolizing enzymes in the tapeworm Moniezia expansa.
Parasitology
; 142(5): 648-59, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25373326
16.
Uncharged mono- and bisoximes: In search of a zwitterion to countermeasure organophosphorus intoxication.
Chem Biol Interact
; 394: 110941, 2024 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38493910
17.
Morphing cholinesterase inhibitor amiridine into multipotent drugs for the treatment of Alzheimer's disease.
Biomed Pharmacother
; 173: 116399, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38492439
18.
Phenoxytacrine derivatives: Low-toxicity neuroprotectants exerting affinity to ifenprodil-binding site and cholinesterase inhibition.
Eur J Med Chem
; 266: 116130, 2024 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38218127
19.
BODIPY-labelled acetylcholinesterase reactivators can be encapsulated into ferritin nanovehicles for enhanced bioavailability in the CNS.
Biomed Pharmacother
; 167: 115490, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37722189
20.
Tacrine First-Phase Biotransformation and Associated Hepatotoxicity: A Possible Way to Avoid Quinone Methide Formation.
ACS Chem Biol
; 18(9): 1993-2002, 2023 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37622522