Detalhe da pesquisa
1.
2-Amino-1,3,4-thiadiazoles in the 7-hydroxy-N-neopentyl spiropiperidine indolinyl series as potent P2Y1 receptor antagonists.
Bioorg Med Chem Lett
; 24(11): 2481-5, 2014 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24767843
2.
Identification of 1-{2-[4-chloro-1'-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent, efficacious and orally bioavailable P2Y(1) antagonist as an antiplatelet agent.
Bioorg Med Chem Lett
; 24(5): 1294-8, 2014 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24513044
3.
New azole antagonists with high affinity for the P2Y(1) receptor.
Bioorg Med Chem Lett
; 23(12): 3519-22, 2013 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23668989
4.
Potent P2Y1 urea antagonists bearing various cyclic amine scaffolds.
Bioorg Med Chem Lett
; 23(24): 6825-8, 2013 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24269480
5.
Discovery of diarylurea P2Y(1) antagonists with improved aqueous solubility.
Bioorg Med Chem Lett
; 23(11): 3239-43, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23602442
6.
Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson's Disease.
ACS Med Chem Lett
; 14(2): 146-155, 2023 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36793422
7.
Discovery of 4-aryl-7-hydroxyindoline-based P2Y1 antagonists as novel antiplatelet agents.
J Med Chem
; 57(14): 6150-64, 2014 Jul 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-24931384
8.
4-Benzothiazole-7-hydroxyindolinyl diaryl ureas are potent P2Y1 antagonists with favorable pharmacokinetics: low clearance and small volume of distribution.
ChemMedChem
; 9(10): 2327-43, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-24989964
9.
Discovery of 2-(phenoxypyridine)-3-phenylureas as small molecule P2Y1 antagonists.
J Med Chem
; 56(4): 1704-14, 2013 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-23368907
10.
Conformationally constrained ortho-anilino diaryl ureas: discovery of 1-(2-(1'-neopentylspiro[indoline-3,4'-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a potent, selective, and bioavailable P2Y1 antagonist.
J Med Chem
; 56(22): 9275-95, 2013 Nov 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24164581
11.
Biomarker optimization to track the antithrombotic and hemostatic effects of clopidogrel in rats.
J Pharmacol Exp Ther
; 322(1): 369-77, 2007 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-17420297