Detalhe da pesquisa
1.
A randomized study of the safety and pharmacokinetics of GSK3358699, a mononuclear myeloid-targeted bromodomain and extra-terminal domain inhibitor.
Br J Clin Pharmacol
; 88(5): 2140-2155, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34773923
2.
Lysine specific demethylase 1 inactivation enhances differentiation and promotes cytotoxic response when combined with all-trans retinoic acid in acute myeloid leukemia across subtypes.
Haematologica
; 104(6): 1156-1167, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30514804
3.
Treatment with an antibody directed against Nogo-A delays disease progression in the SOD1G93A mouse model of Amyotrophic lateral sclerosis.
Hum Mol Genet
; 23(16): 4187-200, 2014 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24667415
4.
Tyrosine Kinase 2 Signalling Drives Pathogenic T cells in Colitis.
J Crohns Colitis
; 15(4): 617-630, 2021 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33005945
5.
Phase 1 Study of Molibresib (GSK525762), a Bromodomain and Extra-Terminal Domain Protein Inhibitor, in NUT Carcinoma and Other Solid Tumors.
JNCI Cancer Spectr
; 4(2): pkz093, 2020 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-32328561
6.
Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss.
Cancer Cell
; 36(1): 100-114.e25, 2019 07 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31257072
7.
Signaling function of PRC2 is essential for TCR-driven T cell responses.
J Exp Med
; 215(4): 1101-1113, 2018 04 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29523590
8.
The commonly used PI3-kinase probe LY294002 is an inhibitor of BET bromodomains.
ACS Chem Biol
; 9(2): 495-502, 2014 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-24533473