Detalhe da pesquisa
1.
Significant Differences in Capsid Properties and Potency Between Adeno-Associated Virus Vectors Produced in Sf9 and HEK293 Cells.
Hum Gene Ther
; 34(19-20): 1003-1021, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37597192
2.
P4 capped amides and lactams as HCV NS3 protease inhibitors with improved potency and DMPK profile.
Bioorg Med Chem Lett
; 20(2): 567-70, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20004570
3.
The introduction of P4 substituted 1-methylcyclohexyl groups into Boceprevir: a change in direction in the search for a second generation HCV NS3 protease inhibitor.
Bioorg Med Chem Lett
; 20(8): 2617-21, 2010 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20303756
4.
Thermodynamics of nucleotide and inhibitor binding to wild-type and ispinesib-resistant forms of human kinesin spindle protein.
Biochemistry
; 48(46): 11045-55, 2009 Nov 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-19824700
5.
Potent inhibitors of HCV-NS3 protease derived from boronic acids.
Bioorg Med Chem Lett
; 19(1): 180-3, 2009 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19022670
6.
Discovery of novel P3 sulfonamide-capped inhibitors of HCV NS3 protease. Inhibitors with improved cellular potencies.
Bioorg Med Chem
; 17(13): 4486-95, 2009 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19481946
7.
Screening for antiviral inhibitors of the HIV integrase-LEDGF/p75 interaction using the AlphaScreen luminescent proximity assay.
J Biomol Screen
; 13(5): 406-14, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18480474
8.
Characterization of resistance mutations against HCV ketoamide protease inhibitors.
Antiviral Res
; 77(3): 177-85, 2008 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-18201776
9.
Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization.
J Med Chem
; 50(10): 2310-8, 2007 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-17444623
10.
Application of ring-closing metathesis for the synthesis of macrocyclic peptidomimetics as inhibitors of HCV NS3 protease.
Org Lett
; 9(16): 3061-4, 2007 Aug 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-17608487
11.
Potent 7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid-based macrocyclic inhibitors of hepatitis C virus NS3 protease.
J Med Chem
; 49(2): 567-74, 2006 Jan 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-16420042
12.
Novel potent hepatitis C virus NS3 serine protease inhibitors derived from proline-based macrocycles.
J Med Chem
; 49(3): 995-1005, 2006 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-16451065
13.
Discovery of SCH446211 (SCH6): a new ketoamide inhibitor of the HCV NS3 serine protease and HCV subgenomic RNA replication.
J Med Chem
; 49(9): 2750-7, 2006 May 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-16640336
14.
Discovery of (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a selective, potent, orally bioavailable hepatitis C virus NS3 protease inhibitor: a potential therapeutic agent for the treatment of hepatitis C infection.
J Med Chem
; 49(20): 6074-86, 2006 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-17004721
15.
Design and synthesis of depeptidized macrocyclic inhibitors of hepatitis C NS3-4A protease using structure-based drug design.
J Med Chem
; 48(16): 5088-91, 2005 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-16078825
16.
Design, synthesis, and biological activity of m-tyrosine-based 16- and 17-membered macrocyclic inhibitors of hepatitis C virus NS3 serine protease.
J Med Chem
; 48(20): 6229-35, 2005 Oct 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-16190750
17.
Identification of an adeno-associated virus binding epitope for AVB sepharose affinity resin.
Mol Ther Methods Clin Dev
; 2: 15040, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26605372
18.
Application of the lambda-dynamics method to evaluate the relative binding free energies of inhibitors to HCV protease.
J Med Chem
; 46(25): 5360-4, 2003 Dec 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-14640544
19.
Proline-based macrocyclic inhibitors of the hepatitis C virus: stereoselective synthesis and biological activity.
Angew Chem Int Ed Engl
; 44(43): 7024-8, 2005 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-16211639
20.
Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor.
ACS Med Chem Lett
; 1(2): 64-9, 2010 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900178