Detalhe da pesquisa
1.
Differential Sarcomere and Electrophysiological Maturation of Human iPSC-Derived Cardiac Myocytes in Monolayer vs. Aggregation-Based Differentiation Protocols.
Int J Mol Sci
; 18(6)2017 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28587156
2.
Synthesis and multiparametric evaluation of thiadiazoles and oxadiazoles as diacylglycerol acyltransferase type 1 inhibitors.
Bioorg Med Chem Lett
; 26(1): 25-32, 2016 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26627579
3.
Synthesis, characterization, and biological assessment of the four stereoisomers of the H(3) receptor antagonist 5-fluoro-2-methyl-N-[2-methyl-4-(2-methyl[1,3']bipyrrolidinyl-1'-yl)phenyl]benzamide.
Bioorg Med Chem Lett
; 23(14): 4044-7, 2013 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23769643
4.
Discovery of aryl ureas and aryl amides as potent and selective histamine H3 receptor antagonists for the treatment of obesity (part I).
Bioorg Med Chem Lett
; 23(11): 3416-20, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23591110
5.
Discovery of aryl ureas and aryl amides as potent and selective histamine H3 receptor antagonists for the treatment of obesity (part II).
Bioorg Med Chem Lett
; 23(11): 3421-6, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23591112
6.
Discovery of SAR184841, a potent and long-lasting inhibitor of 11ß-hydroxysteroid dehydrogenase type 1, active in a physiopathological animal model of T2D.
Bioorg Med Chem Lett
; 23(8): 2414-21, 2013 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23478147
7.
Thiadiazoles as new inhibitors of diacylglycerol acyltransferase type 1.
Bioorg Med Chem Lett
; 22(7): 2497-502, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22405833
8.
Lipoprotein(a) Cellular Uptake Ex Vivo and Hepatic Capture In Vivo Is Insensitive to PCSK9 Inhibition With Alirocumab.
JACC Basic Transl Sci
; 5(6): 549-557, 2020 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-32613143
9.
Reversion of cardiac dysfunction by a novel orally available calcium/calmodulin-dependent protein kinase II inhibitor, RA306, in a genetic model of dilated cardiomyopathy.
Cardiovasc Res
; 116(2): 329-338, 2020 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31038167
10.
Recent advances in PDE4 inhibitors as immunoregulators and anti-inflammatory drugs.
Curr Pharm Des
; 8(14): 1255-96, 2002.
Artigo
em Inglês
| MEDLINE | ID: mdl-12052219
11.
Modulation of matrix metalloproteinase production from human lung fibroblasts by type 4 phosphodiesterase inhibitors.
Life Sci
; 75(7): 823-40, 2004 Jul 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-15183075
12.
SAR110894, a potent histamine H3-receptor antagonist, displays procognitive effects in rodents.
Pharmacol Biochem Behav
; 102(2): 203-14, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22542742
13.
The central cannabinoid CB1 receptor is required for diet-induced obesity and rimonabant's antiobesity effects in mice.
Obesity (Silver Spring)
; 19(10): 1923-34, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21799481
14.
Relationship between phosphodiesterase type 4 inhibition and anti-inflammatory activity of CI-1044 in rat airways.
Fundam Clin Pharmacol
; 24(1): 73-82, 2010 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-19650853
15.
Localization and phenotypic characterization of brainstem neurons activated by rimonabant and WIN55,212-2.
Brain Res Bull
; 78(4-5): 202-10, 2009 Mar 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-19038314
16.
Adiponectin is required to mediate rimonabant-induced improvement of insulin sensitivity but not body weight loss in diet-induced obese mice.
Am J Physiol Regul Integr Comp Physiol
; 296(4): R929-35, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19211723
17.
Beneficial effect of a chronic treatment with rimonabant on pancreatic function and beta-cell morphology in Zucker Fatty rats.
Eur J Pharmacol
; 616(1-3): 314-20, 2009 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19482020
18.
Cutting edge: chemoattractant receptor-homologous molecule expressed on Th2 cells plays a restricting role on IL-5 production and eosinophil recruitment.
J Immunol
; 175(4): 2056-60, 2005 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16081770
19.
Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation.
J Immunol
; 173(12): 7531-8, 2004 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15585880