Detalhe da pesquisa
1.
Discovery and characterization of novel TRPML1 agonists.
Bioorg Med Chem Lett
; 98: 129595, 2024 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38141860
2.
Automated Generation of Novel Fragments Using Screening Data, a Dual SMILES Autoencoder, Transfer Learning and Syntax Correction.
J Chem Inf Model
; 61(6): 2547-2559, 2021 06 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34029470
3.
Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents.
Bioorg Med Chem Lett
; 29(8): 1023-1029, 2019 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30773430
4.
Eriodictyol inhibits RSK2-ATF1 signaling and suppresses EGF-induced neoplastic cell transformation.
J Biol Chem
; 286(3): 2057-66, 2011 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-21098035
5.
Implementation of an AI-assisted fragment-generator in an open-source platform.
RSC Med Chem
; 13(10): 1205-1211, 2022 Oct 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-36320432
6.
Stabilization of the RAS:PDE6D Complex Is a Novel Strategy to Inhibit RAS Signaling.
J Med Chem
; 65(3): 1898-1914, 2022 02 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35104933
7.
Role of NEK6 in tumor promoter-induced transformation in JB6 C141 mouse skin epidermal cells.
J Biol Chem
; 285(36): 28126-33, 2010 Sep 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-20595392
8.
The resveratrol analogue 3,5,3',4',5'-pentahydroxy-trans-stilbene inhibits cell transformation via MEK.
Int J Cancer
; 123(11): 2487-96, 2008 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18767048
9.
Herbacetin Is a Novel Allosteric Inhibitor of Ornithine Decarboxylase with Antitumor Activity.
Cancer Res
; 76(5): 1146-1157, 2016 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26676750
10.
Identification of a Selective G1-Phase Benzimidazolone Inhibitor by a Senescence-Targeted Virtual Screen Using Artificial Neural Networks.
Neoplasia
; 17(9): 704-715, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26476078
11.
Fragment-based hit identification: thinking in 3D.
Drug Discov Today
; 18(23-24): 1221-7, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-23906694
12.
Computational tools and resources for metabolism-related property predictions. 2. Application to prediction of half-life time in human liver microsomes.
Future Med Chem
; 4(15): 1933-44, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23088274
13.
Computational tools and resources for metabolism-related property predictions. 1. Overview of publicly available (free and commercial) databases and software.
Future Med Chem
; 4(15): 1907-32, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23088273
14.
Software and resources for computational medicinal chemistry.
Future Med Chem
; 3(8): 1057-85, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21707404
15.
Anti-cancer gallotannin penta-O-galloyl-beta-D-glucose is a nanomolar inhibitor of select mammalian DNA polymerases.
Biochem Pharmacol
; 80(8): 1125-32, 2010 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20599777
16.
Resveratrol, a red wine polyphenol, suppresses pancreatic cancer by inhibiting leukotriene A4hydrolase.
Cancer Res
; 70(23): 9755-64, 2010 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20952510
17.
A regulatory mechanism for RSK2 NH(2)-terminal kinase activity.
Cancer Res
; 69(10): 4398-406, 2009 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19435896
18.
Cyclin-dependent kinase-3-mediated c-Jun phosphorylation at Ser63 and Ser73 enhances cell transformation.
Cancer Res
; 69(1): 272-81, 2009 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19118012
19.
[6]-Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase.
Cancer Res
; 69(13): 5584-91, 2009 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19531649
20.
(-)-Epigallocatechin gallate regulates CD3-mediated T cell receptor signaling in leukemia through the inhibition of ZAP-70 kinase.
J Biol Chem
; 283(42): 28370-9, 2008 Oct 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-18687687