RESUMO
We discuss imiquimod associated with non-application site mucosal reactions and two of our own clinical cases. In one of our patients, erosive cheilitis developed in a young boy after using topical imiquimod 5% cream for 5 nights weekly on bilateral cheeks, chin, and near vermillion border for molluscum contagiosum. The case is discussed with concerns for imiquimod use in molluscum contagiosum when used near mucosal surfaces.
Assuntos
Adjuvantes Imunológicos/uso terapêutico , Queilite/induzido quimicamente , Imiquimode/uso terapêutico , Molusco Contagioso/tratamento farmacológico , Adjuvantes Imunológicos/efeitos adversos , Queilite/etiologia , Criança , Humanos , Imiquimode/efeitos adversos , MasculinoRESUMO
A 42-year-old Latino man with a medical history of vitiligo presented to our outpatient clinic with a 25-year history of a recurrent, itchy eruption on his face and hands. Physical examination revealed pink, scaly, erythematous, lichenified papules and plaques with overlying crusts, photodistributed on the nose, chin, cheeks, hands, and ears (Figures 1a and 2a). The lips were edematous with hemorrhagic crusting, and conjunctival injection and partial corneal opacities were noted (Figures 1b-1c). Histologic evaluation demonstrated psoriasiform hyperplasia with hyper-granulosis and a superficial perivascular infiltrate composed of lymphocytes, histiocytes, and eosinophils. Human leukocyte antigen (HLA) class II typing was positive for HLA-DRB1*0407, thus confirming the diagnosis of actinic prurigo (AP).
Assuntos
Anticorpos Monoclonais Humanizados/uso terapêutico , Transtornos de Fotossensibilidade , Dermatopatias Genéticas , Adulto , Humanos , Masculino , Transtornos de Fotossensibilidade/tratamento farmacológico , Dermatopatias Genéticas/tratamento farmacológicoAssuntos
Anorexia , Neoplasias Cutâneas , Anorexia/etiologia , Humanos , Neoplasias Cutâneas/diagnósticoRESUMO
BACKGROUND: Atopic dermatitis is an inflammatory skin disease that frequently affects children. The current recommendations on management using lifestyle modification are highly variable, leading to confusion and uncertainty among patients. AIM: To determine current bathing behaviors and the subsequent impact on disease severity. METHODS: This was an observational cross-sectional study conducted at an urban pediatric emergency department. Parents were asked to fill out a questionnaire concerning the patient's bathing habits. The results were correlated with the atopic dermatitis severity determined by the SCORAD (SCORing Atopic Dermatitis) tool. RESULTS: No difference between variables was found to be significant for bathing frequency, time spent bathing, or use of moisturizers. Multivariate analysis showed that atopic dermatitis severity increased with age greater than 2 years (P = .0004) and with greater bathing duration (P = .001). CONCLUSION: Atopic dermatitis severity may be associated with a longer duration of bathing. The frequency of bathing does not appear to affect atopic dermatitis severity.