RESUMO
OBJECTIVE: To study pharmacokinetics of honokiol in Cortex of Magnolia officinalis and its compound prescription Houpu Sanwu Decoction (HPSWD) in rat, and discuss the change on pharmacokinetic process affected by other components. METHODS: The rats were divided into two groups, one was supplied with HPSWD and the other was administrated with Cortex of Magnolia officinalis. Concentrations of honokiol in rat plasma were then determined using HPLC method and main pharmacokinetic parameters were estimated. RESULTS: The plasma concentrations of honokiol of both groups were conformed to the two-compartment model with first order absorption. There existed significant differences in AUC, C(max), T(max), CL/F among Cortex of Magnolia officinalis and HPSWD. CONCLUSION: The results indicate that Rhubarb and Immature Orange Fruit in HPSWD can influence the asorption, distribution and elimination of honokiol.