Detalhe da pesquisa
1.
Cas9 degradation in human cells using phage anti-CRISPR proteins.
PLoS Biol
; 21(12): e3002431, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-38064533
2.
Discovery and engineering of AiEvo2, a novel Cas12a nuclease for human gene editing applications.
J Biol Chem
; 300(3): 105685, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38272227
3.
Tandem-Cleavage Linkers Improve the In Vivo Stability and Tolerability of Antibody-Drug Conjugates.
Bioconjug Chem
; 32(4): 746-754, 2021 04 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33689309
4.
CRISPR-Cas9 screens identify regulators of antibody-drug conjugate toxicity.
Nat Chem Biol
; 15(10): 949-958, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31451760
5.
Hydrophilic Sequence-Defined Cross-Linkers for Antibody-Drug Conjugates.
Bioconjug Chem
; 30(11): 2982-2988, 2019 11 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31671265
6.
Rapid Characterization of a Mechanically Labile α-Helical Protein Enabled by Efficient Site-Specific Bioconjugation.
J Am Chem Soc
; 139(29): 9867-9875, 2017 07 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28677396
7.
Reconstitution of Formylglycine-generating Enzyme with Copper(II) for Aldehyde Tag Conversion.
J Biol Chem
; 290(25): 15730-15745, 2015 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-25931126
8.
Generating aldehyde-tagged antibodies with high titers and high formylglycine yields by supplementing culture media with copper(II).
BMC Biotechnol
; 16: 23, 2016 Feb 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26911368
9.
A Pictet-Spengler ligation for protein chemical modification.
Proc Natl Acad Sci U S A
; 110(1): 46-51, 2013 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-23237853
10.
A modular approach for assembling aldehyde-tagged proteins on DNA scaffolds.
J Am Chem Soc
; 136(31): 10850-3, 2014 Aug 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-25029632
11.
Aldehyde tag coupled with HIPS chemistry enables the production of ADCs conjugated site-specifically to different antibody regions with distinct in vivo efficacy and PK outcomes.
Bioconjug Chem
; 25(7): 1331-41, 2014 Jul 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-24924618
12.
Viral Delivery of Compact CRISPR-Cas12f for Gene Editing Applications.
CRISPR J
; 2024 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38695159
13.
Hydrazino-Pictet-Spengler ligation as a biocompatible method for the generation of stable protein conjugates.
Bioconjug Chem
; 24(6): 846-51, 2013 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-23731037
14.
Discovery and Characterization of Novel Type V Cas12f Nucleases with Diverse Protospacer Adjacent Motif Preferences.
CRISPR J
; 6(4): 350-358, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37267210
15.
Site-specific chemical modification of recombinant proteins produced in mammalian cells by using the genetically encoded aldehyde tag.
Proc Natl Acad Sci U S A
; 106(9): 3000-5, 2009 Mar 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-19202059
16.
A Novel HER2-targeted Antibody-drug Conjugate Offers the Possibility of Clinical Dosing at Trastuzumab-equivalent Exposure Levels.
Mol Cancer Ther
; 19(9): 1866-1874, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32651200
17.
Control of the molecular orientation of membrane-anchored biomimetic glycopolymers.
J Am Chem Soc
; 131(29): 10263-8, 2009 Jul 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-19580278
18.
Synthesis and microcontact printing of dual end-functionalized mucin-like glycopolymers for microarray applications.
Angew Chem Int Ed Engl
; 48(27): 4973-6, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19479916
19.
Site-Specific Labeling of Proteins Using the Formylglycine-Generating Enzyme (FGE).
Methods Mol Biol
; 2012: 63-81, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31161504
20.
Site-Specific Bioconjugation Using SMARTag® Technology: A Practical and Effective Chemoenzymatic Approach to Generate Antibody-Drug Conjugates.
Methods Mol Biol
; 2033: 131-147, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31332752