Pesquisa | Biblioteca Virtual em Saúde

1.

A highly conserved program of neuronal microexons is misregulated in autistic brains.

Irimia, Manuel; Weatheritt, Robert J; Ellis, Jonathan D; Parikshak, Neelroop N; Gonatopoulos-Pournatzis, Thomas; Babor, Mariana; Quesnel-Vallières, Mathieu; Tapial, Javier; Raj, Bushra; O'Hanlon, Dave; Barrios-Rodiles, Miriam; Sternberg, Michael J E; Cordes, Sabine P; Roth, Frederick P; Wrana, Jeffrey L; Geschwind, Daniel H; Blencowe, Benjamin J.

Cell ; 159(7): 1511-23, 2014 Dec 18.

Artigo em Inglês | MEDLINE | ID: mdl-25525873

2.

Genome-wide CRISPR-Cas9 Interrogation of Splicing Networks Reveals a Mechanism for Recognition of Autism-Misregulated Neuronal Microexons.

Gonatopoulos-Pournatzis, Thomas; Wu, Mingkun; Braunschweig, Ulrich; Roth, Jonathan; Han, Hong; Best, Andrew J; Raj, Bushra; Aregger, Michael; O'Hanlon, Dave; Ellis, Jonathan D; Calarco, John A; Moffat, Jason; Gingras, Anne-Claude; Blencowe, Benjamin J.

Mol Cell ; 72(3): 510-524.e12, 2018 11 01.

Artigo em Inglês | MEDLINE | ID: mdl-30388412

3.

Regulation of vertebrate nervous system alternative splicing and development by an SR-related protein.

Calarco, John A; Superina, Simone; O'Hanlon, Dave; Gabut, Mathieu; Raj, Bushra; Pan, Qun; Skalska, Ursula; Clarke, Laura; Gelinas, Danielle; van der Kooy, Derek; Zhen, Mei; Ciruna, Brian; Blencowe, Benjamin J.

Cell ; 138(5): 898-910, 2009 Sep 04.

Artigo em Inglês | MEDLINE | ID: mdl-19737518

4.

A global regulatory mechanism for activating an exon network required for neurogenesis.

Raj, Bushra; Irimia, Manuel; Braunschweig, Ulrich; Sterne-Weiler, Timothy; O'Hanlon, Dave; Lin, Zhen-Yuan; Chen, Ginny I; Easton, Laura E; Ule, Jernej; Gingras, Anne-Claude; Eyras, Eduardo; Blencowe, Benjamin J.

Mol Cell ; 56(1): 90-103, 2014 Oct 02.

Artigo em Inglês | MEDLINE | ID: mdl-25219497

5.

Tracing developmental lineages.

Raj, Bushra.

Nat Methods ; 20(12): 1852-1854, 2023 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-38057508

6.

Cross-regulation between an alternative splicing activator and a transcription repressor controls neurogenesis.

Raj, Bushra; O'Hanlon, Dave; Vessey, John P; Pan, Qun; Ray, Debashish; Buckley, Noel J; Miller, Freda D; Blencowe, Benjamin J.

Mol Cell ; 43(5): 843-50, 2011 Sep 02.

Artigo em Inglês | MEDLINE | ID: mdl-21884984

7.

Emergence of Neuronal Diversity during Vertebrate Brain Development.

Raj, Bushra; Farrell, Jeffrey A; Liu, Jialin; El Kholtei, Jakob; Carte, Adam N; Navajas Acedo, Joaquin; Du, Lucia Y; McKenna, Aaron; Relic, Dorde; Leslie, Jessica M; Schier, Alexander F.

Neuron ; 108(6): 1058-1074.e6, 2020 12 23.

Artigo em Inglês | MEDLINE | ID: mdl-33068532

8.

Large-scale reconstruction of cell lineages using single-cell readout of transcriptomes and CRISPR-Cas9 barcodes by scGESTALT.

Raj, Bushra; Gagnon, James A; Schier, Alexander F.

Nat Protoc ; 13(11): 2685-2713, 2018 11.

Artigo em Inglês | MEDLINE | ID: mdl-30353175

9.

Simultaneous single-cell profiling of lineages and cell types in the vertebrate brain.

Raj, Bushra; Wagner, Daniel E; McKenna, Aaron; Pandey, Shristi; Klein, Allon M; Shendure, Jay; Gagnon, James A; Schier, Alexander F.

Nat Biotechnol ; 36(5): 442-450, 2018 06.

Artigo em Inglês | MEDLINE | ID: mdl-29608178

10.

Alternative Splicing in the Mammalian Nervous System: Recent Insights into Mechanisms and Functional Roles.

Raj, Bushra; Blencowe, Benjamin J.

Neuron ; 87(1): 14-27, 2015 Jul 01.

Artigo em Inglês | MEDLINE | ID: mdl-26139367

11.

An alternative splicing event amplifies evolutionary differences between vertebrates.

Gueroussov, Serge; Gonatopoulos-Pournatzis, Thomas; Irimia, Manuel; Raj, Bushra; Lin, Zhen-Yuan; Gingras, Anne-Claude; Blencowe, Benjamin J.

Science ; 349(6250): 868-73, 2015 Aug 21.

Artigo em Inglês | MEDLINE | ID: mdl-26293963

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