Detalhe da pesquisa
1.
Development and validation of an LC-MS/MS method for the determination of ARN14988, an acid ceramidase inhibitor, and its application to a pharmacokinetic study in a mouse model.
Biomed Chromatogr
; 38(1): e5754, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-37750452
2.
Structural Analogs of the GABAkine KRM-II-81 Are Orally Bioavailable Anticonvulsants without Sedation.
J Pharmacol Exp Ther
; 385(1): 50-61, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36746611
3.
The Positive Allosteric Modulator of α2/3-Containing GABAA Receptors, KRM-II-81, Is Active in Pharmaco-Resistant Models of Epilepsy and Reduces Hyperexcitability after Traumatic Brain Injury.
J Pharmacol Exp Ther
; 372(1): 83-94, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31694876
4.
Modulating native GABAA receptors in medulloblastoma with positive allosteric benzodiazepine-derivatives induces cell death.
J Neurooncol
; 142(3): 411-422, 2019 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-30725256
5.
GABAA Receptor Subtypes and the Abuse-Related Effects of Ethanol in Rhesus Monkeys: Experiments with Selective Positive Allosteric Modulators.
Alcohol Clin Exp Res
; 43(5): 791-802, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30861153
6.
Effects of α5 GABAA receptor modulation on social interaction, memory, and neuroinflammation in a mouse model of Alzheimer's disease.
CNS Neurosci Ther
; 28(11): 1767-1778, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35822698
7.
Positive and Negative Selective Allosteric Modulators of α5 GABAA Receptors: Effects on Emotionality, Motivation, and Motor Function in the 5xFAD Model of Alzheimer's Disease.
J Alzheimers Dis
; 84(3): 1291-1302, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34657887
8.
An efficient debromination technique using PMHS with a number of ligands containing different functional groups.
ARKIVOC
; 2021(5): 171-188, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-38774148
9.
Imidazodiazepine Anticonvulsant, KRM-II-81, Produces Novel, Non-diazepam-like Antiseizure Effects.
ACS Chem Neurosci
; 11(17): 2624-2637, 2020 09 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32786313
10.
Design, synthesis and characterization of novel gammaaminobutyric acid type A receptor ligands.
ARKIVOC
; 2020(Pt 7): 242-256, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33642954
11.
Non-sedating benzodiazepines cause paralysis and tissue damage in the parasitic blood fluke Schistosoma mansoni.
PLoS Negl Trop Dis
; 13(11): e0007826, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31730614
12.
The value of human epileptic tissue in the characterization and development of novel antiepileptic drugs: The example of CERC-611 and KRM-II-81.
Brain Res
; 1722: 146356, 2019 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31369732
13.
Improved Synthesis of Anxiolytic, Anticonvulsant and Antinociceptive α2/α3-GABA(A)ergic Receptor Subtype Selective Ligands as Promising Agents to Treat Anxiety, Epilepsy, as well as Neuropathic Pain.
Synthesis (Stuttg)
; 50(20): 4124-4132, 2018 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-32773890