Detalhe da pesquisa
1.
Activating STING1-dependent immune signaling in TP53 mutant and wild-type acute myeloid leukemia.
Proc Natl Acad Sci U S A
; 119(27): e2123227119, 2022 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35759659
2.
Pharmacologic induction of innate immune signaling directly drives homologous recombination deficiency.
Proc Natl Acad Sci U S A
; 117(30): 17785-17795, 2020 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32651270
3.
DNA methyltransferase inhibitors induce a BRCAness phenotype that sensitizes NSCLC to PARP inhibitor and ionizing radiation.
Proc Natl Acad Sci U S A
; 116(45): 22609-22618, 2019 11 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31591209
4.
Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile.
Blood
; 122(7): 1293-304, 2013 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23836560
5.
DNA double-strand break response in stem cells: mechanisms to maintain genomic integrity.
Biochim Biophys Acta
; 1830(2): 2345-53, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22995214
6.
Defective nonhomologous end joining blocks B-cell development in FLT3/ITD mice.
Blood
; 117(11): 3131-9, 2011 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-21228325
7.
Pharmacologic Induction of BRCAness in BRCA-Proficient Cancers: Expanding PARP Inhibitor Use.
Cancers (Basel)
; 14(11)2022 May 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-35681619
8.
PARP1 PARylates and stabilizes STAT5 in FLT3-ITD acute myeloid leukemia and other STAT5-activated cancers.
Transl Oncol
; 15(1): 101283, 2022 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-34808460
9.
Phase I Clinical Trial of DNA Methyltransferase Inhibitor Decitabine and PARP Inhibitor Talazoparib Combination Therapy in Relapsed/Refractory Acute Myeloid Leukemia.
Clin Cancer Res
; 28(7): 1313-1322, 2022 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35091444
10.
Targeting abnormal DNA double strand break repair in cancer.
Cell Mol Life Sci
; 67(21): 3699-710, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20697770
11.
How Epigenetic Therapy Beats Adverse Genetics in Monosomy Karyotype AML.
Cancer Res
; 81(4): 813-815, 2021 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33822747
12.
Pim kinase inhibitor co-treatment decreases alternative non-homologous end-joining DNA repair and genomic instability induced by topoisomerase 2 inhibitors in cells with FLT3 internal tandem duplication.
Oncotarget
; 12(18): 1763-1779, 2021 Aug 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-34504649
13.
Up-regulation of WRN and DNA ligase IIIalpha in chronic myeloid leukemia: consequences for the repair of DNA double-strand breaks.
Blood
; 112(4): 1413-23, 2008 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18524993
14.
Reactive oxygen species, DNA damage, and error-prone repair: a model for genomic instability with progression in myeloid leukemia?
Cancer Res
; 67(18): 8762-71, 2007 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17875717
15.
Partnering with PARP inhibitors in acute myeloid leukemia with FLT3-ITD.
Cancer Lett
; 454: 171-178, 2019 07 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30953707
16.
Exploiting epigenetically mediated changes: Acute myeloid leukemia, leukemia stem cells and the bone marrow microenvironment.
Adv Cancer Res
; 141: 213-253, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30691684
17.
An Effective Epigenetic-PARP Inhibitor Combination Therapy for Breast and Ovarian Cancers Independent of BRCA Mutations.
Clin Cancer Res
; 24(13): 3163-3175, 2018 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29615458
18.
Histone deacetylase inhibitors (HDI) cause DNA damage in leukemia cells: a mechanism for leukemia-specific HDI-dependent apoptosis?
Mol Cancer Res
; 4(8): 563-73, 2006 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16877702
19.
CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes.
Cancer Cell
; 31(5): 653-668.e7, 2017 05 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28486105
20.
Molecular cloning of Chinese hamster 1q31 chromosomal fragile site DNA that is important to mdr1 gene amplification reveals a novel gene whose expression is associated with spermatocyte and adipocyte differentiation.
Gene
; 372: 44-52, 2006 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-16545529