Detalhe da pesquisa
1.
Atomic modelling and systematic mutagenesis identify residues in multiple drug binding sites that are essential for drug resistance in the major Candida transporter Cdr1.
Biochim Biophys Acta
; 1858(11): 2858-2870, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27569110
2.
Multidrug ABC transporter Cdr1 of Candida albicans harbors specific and overlapping binding sites for human steroid hormones transport.
Biochim Biophys Acta Biomembr
; 1859(10): 1778-1789, 2017 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-28559186
3.
Lathyrol and epoxylathyrol derivatives: Modulation of Cdr1p and Mdr1p drug-efflux transporters of Candida albicans in Saccharomyces cerevisiae model.
Bioorg Med Chem
; 25(13): 3278-3284, 2017 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28479022
4.
Evaluation of Jatrophane Esters from Euphorbia spp. as Modulators of Candida albicans Multidrug Transporters.
J Nat Prod
; 80(2): 479-487, 2017 02 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28106996
5.
Withdrawal: Rationally designed transmembrane peptide mimics of the multidrug transporter protein Cdr1 act as antagonists to selectively block drug efflux and chemosensitize azole-resistant clinical isolates of Candida albicans.
J Biol Chem
; 295(10): 3393, 2020 03 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32144156
6.
Overcoming Multidrug Resistance in Candida albicans: Macrocyclic Diterpenes from Euphorbia Species as Potent Inhibitors of Drug Efflux Pumps.
Planta Med
; 82(13): 1180-5, 2016 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-27145238
7.
Antifungals: Mechanism of Action and Drug Resistance.
Adv Exp Med Biol
; 892: 327-349, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26721281
8.
Candida Efflux ATPases and Antiporters in Clinical Drug Resistance.
Adv Exp Med Biol
; 892: 351-376, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26721282
9.
ABC transporter Cdr1p harbors charged residues in the intracellular loop and nucleotide-binding domain critical for protein trafficking and drug resistance.
FEMS Yeast Res
; 15(5): fov036, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26048893
10.
Rationally designed transmembrane peptide mimics of the multidrug transporter protein Cdr1 act as antagonists to selectively block drug efflux and chemosensitize azole-resistant clinical isolates of Candida albicans.
J Biol Chem
; 288(23): 16775-16787, 2013 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-23592791
11.
Insight into pleiotropic drug resistance ATP-binding cassette pump drug transport through mutagenesis of Cdr1p transmembrane domains.
J Biol Chem
; 288(34): 24480-93, 2013 Aug 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-23824183
12.
Jatrophanes from Euphorbia squamosa as potent inhibitors of Candida albicans multidrug transporters.
J Nat Prod
; 77(12): 2700-6, 2014 Dec 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25437914
13.
Molecular Basis of Substrate Polyspecificity of the Candida albicans Mdr1p Multidrug/H+ Antiporter.
J Mol Biol
; 430(5): 682-694, 2018 03 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29341887
14.
Newly identified motifs in Candida albicans Cdr1 protein nucleotide binding domains are pleiotropic drug resistance subfamily-specific and functionally asymmetric.
Sci Rep
; 6: 27132, 2016 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27251950
15.
Mutational Analysis of Intracellular Loops Identify Cross Talk with Nucleotide Binding Domains of Yeast ABC Transporter Cdr1p.
Sci Rep
; 5: 11211, 2015 Jun 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26053667
16.
Functionally Relevant Residues of Cdr1p: A Multidrug ABC Transporter of Human Pathogenic Candida albicans.
J Amino Acids
; 2011: 531412, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-22312462
17.
Erratum: Newly identified motifs in Candida albicans Cdr1 protein nucleotide binding domains are pleiotropic drug resistance subfamily-specific and functionally asymmetric.
Sci Rep
; 6: 30221, 2016 07 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-27452273