Detalhe da pesquisa
1.
Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2).
J Med Chem
; 67(6): 4655-4675, 2024 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38462716
2.
ASTX029, a Novel Dual-mechanism ERK Inhibitor, Modulates Both the Phosphorylation and Catalytic Activity of ERK.
Mol Cancer Ther
; 20(10): 1757-1768, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34330842
3.
Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2.
J Med Chem
; 64(16): 12286-12303, 2021 08 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34387469
4.
A Fragment-Derived Clinical Candidate for Antagonism of X-Linked and Cellular Inhibitor of Apoptosis Proteins: 1-(6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-1 H,2 H,3 H-pyrrolo[3,2- b]pyridin-1-yl)-2-[(2 R,5 R)-5-methyl-2-([(3R)-3-methylmorpholin-4-yl]methyl)piperazin-1-yl]ethan-1-one (ASTX660).
J Med Chem
; 61(16): 7314-7329, 2018 08 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-30091600
5.
Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2.
J Med Chem
; 61(11): 4978-4992, 2018 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29775310
6.
Diagnosis and operative management of a perforated de Garengeot hernia.
Int J Surg Case Rep
; 41: 114-116, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-29059610
7.
Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP).
J Med Chem
; 60(11): 4611-4625, 2017 06 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28492317
8.
Discovery of imidazo[1,2-b][1,2,4]triazines as GABA(A) alpha2/3 subtype selective agonists for the treatment of anxiety.
J Med Chem
; 49(4): 1235-8, 2006 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-16480260
9.
An unusual presentation of congenital intestinal malrotation in a nonagenarian.
Int J Surg Case Rep
; 25: 229-33, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27399168
10.
Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP.
J Med Chem
; 58(16): 6574-88, 2015 Aug 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-26218264
11.
Potent, selective inhibitors of fibroblast growth factor receptor define fibroblast growth factor dependence in preclinical cancer models.
Mol Cancer Ther
; 10(9): 1542-52, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21764904