1.
Bioorg Med Chem Lett
; 16(9): 2419-22, 2006 May 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16483772
RESUMO
Anilinoalkynylpyrimidines were prepared and evaluated as dual EGFR/ErbB2 kinase inhibitors. A preference was found for substituted phenyl and heteroaromatic rings attached to the alkyne. In addition, the presence of a potential hydrogen bond donor appended to this ring was favored. Selected molecules in the series demonstrated some activity against human tumor cell lines.