Detalhe da pesquisa
1.
The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism.
Cell
; 165(7): 1632-1643, 2016 Jun 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-27315480
2.
Activation of the GLP-1 receptor by a non-peptidic agonist.
Nature
; 577(7790): 432-436, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31915381
3.
Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor.
Nature
; 561(7724): 492-497, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30209400
4.
Molecular dynamics studies reveal structural and functional features of the SARS-CoV-2 spike protein.
Bioessays
; 44(9): e2200060, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35843871
5.
Patients Who Have a Prior History of Pulmonary Embolism Require Increased Postoperative Care Following Total Joint Arthroplasty.
J Arthroplasty
; 39(5): 1245-1252, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-37924988
6.
Biased agonism and polymorphic variation at the GLP-1 receptor: Implications for the development of personalised therapeutics.
Pharmacol Res
; 184: 106411, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36007775
7.
Multisite Model of Allosterism for the Adenosine A1 Receptor.
J Chem Inf Model
; 61(4): 2001-2015, 2021 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-33779168
8.
Supervised molecular dynamics for exploring the druggability of the SARS-CoV-2 spike protein.
J Comput Aided Mol Des
; 35(2): 195-207, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33103220
9.
A Supervised Molecular Dynamics Approach to Unbiased Ligand-Protein Unbinding.
J Chem Inf Model
; 60(3): 1804-1817, 2020 03 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32126172
10.
Addressing free fatty acid receptor 1 (FFAR1) activation using supervised molecular dynamics.
J Comput Aided Mol Des
; 34(11): 1181-1193, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32851580
11.
Calcitonin Gene-Related Peptide Antagonists and Therapeutic Antibodies.
Handb Exp Pharmacol
; 255: 169-192, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30689083
12.
Photoaffinity Cross-Linking and Unnatural Amino Acid Mutagenesis Reveal Insights into Calcitonin Gene-Related Peptide Binding to the Calcitonin Receptor-like Receptor/Receptor Activity-Modifying Protein 1 (CLR/RAMP1) Complex.
Biochemistry
; 57(32): 4915-4922, 2018 08 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30004692
13.
Genetically encoded photocross-linkers determine the biological binding site of exendin-4 peptide in the N-terminal domain of the intact human glucagon-like peptide-1 receptor (GLP-1R).
J Biol Chem
; 292(17): 7131-7144, 2017 04 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-28283573
14.
Receptor Activity-modifying Protein-directed G Protein Signaling Specificity for the Calcitonin Gene-related Peptide Family of Receptors.
J Biol Chem
; 291(42): 21925-21944, 2016 Oct 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27566546
15.
Receptor Activity-modifying Proteins 2 and 3 Generate Adrenomedullin Receptor Subtypes with Distinct Molecular Properties.
J Biol Chem
; 291(22): 11657-75, 2016 May 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27013657
16.
A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures.
Mol Pharmacol
; 89(3): 335-47, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26700562
17.
Modulation of Glucagon Receptor Pharmacology by Receptor Activity-modifying Protein-2 (RAMP2).
J Biol Chem
; 290(38): 23009-22, 2015 Sep 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26198634
18.
Receptor activity-modifying proteins; multifunctional G protein-coupled receptor accessory proteins.
Biochem Soc Trans
; 44(2): 568-73, 2016 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27068971
19.
One motif to bind them: A small-XXX-small motif affects transmembrane domain 1 oligomerization, function, localization, and cross-talk between two yeast GPCRs.
Biochim Biophys Acta
; 1838(12): 3036-51, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25157670
20.
Do plants contain g protein-coupled receptors?
Plant Physiol
; 164(1): 287-307, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24246381