Detalhe da pesquisa
1.
Phase-separated foci of EML4-ALK facilitate signalling and depend upon an active kinase conformation.
EMBO Rep
; 22(12): e53693, 2021 12 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34661367
2.
Mitotic spindle association of TACC3 requires Aurora-A-dependent stabilization of a cryptic α-helix.
EMBO J
; 37(8)2018 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-29510984
3.
EML4-ALK V3 oncogenic fusion proteins promote microtubule stabilization and accelerated migration through NEK9 and NEK7.
J Cell Sci
; 133(9)2020 05 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32184261
4.
Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors.
Proc Natl Acad Sci U S A
; 113(48): 13726-13731, 2016 11 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-27837025
5.
A moving target: structure and disorder in pursuit of Myc inhibitors.
Biochem Soc Trans
; 45(3): 709-717, 2017 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28620032
6.
An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9.
Mol Cell
; 36(4): 560-70, 2009 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-19941817
7.
Molecular mechanisms that underpin EML4-ALK driven cancers and their response to targeted drugs.
Cell Mol Life Sci
; 73(6): 1209-24, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26755435
8.
Crystal structure of EML1 reveals the basis for Hsp90 dependence of oncogenic EML4-ALK by disruption of an atypical ß-propeller domain.
Proc Natl Acad Sci U S A
; 111(14): 5195-200, 2014 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24706829
9.
Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain.
Biochem J
; 467(3): 529-36, 2015 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25740311
10.
A nanobody inhibitor of Fascin-1 actin-bundling activity and filopodia formation.
Open Biol
; 14(3): 230376, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38503329
11.
Structural basis of poly(ADP-ribose) recognition by the multizinc binding domain of checkpoint with forkhead-associated and RING Domains (CHFR).
J Biol Chem
; 285(50): 39348-58, 2010 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-20880844
12.
Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: insights into selectivity and drug design.
Biochem J
; 427(1): 19-28, 2010 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20067443
13.
2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase.
RSC Med Chem
; 11(6): 707-731, 2020 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33479670
14.
Orally bioavailable CDK9/2 inhibitor shows mechanism-based therapeutic potential in MYCN-driven neuroblastoma.
J Clin Invest
; 130(11): 5875-5892, 2020 11 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33016930
15.
Measurement of clinicians' ability to hand torque dental implant components.
J Oral Implantol
; 35(4): 185-8, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19813423
16.
Repeatability of a dental shade-matching instrument when compared to traditional visual methods of shade evaluation.
Gen Dent
; 57(4): 323-7, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19903610
17.
Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression.
Sci Signal
; 12(594)2019 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31409757
18.
Mitotic phosphorylation regulates Hsp72 spindle localization by uncoupling ATP binding from substrate release.
Sci Signal
; 11(543)2018 08 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30108182
19.
Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem Biol
; 12(11): 2906-2914, 2017 11 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-29045126
20.
Interaction via a key tryptophan in the I-II linker of N-type calcium channels is required for beta1 but not for palmitoylated beta2, implicating an additional binding site in the regulation of channel voltage-dependent properties.
J Neurosci
; 25(30): 6984-96, 2005 Jul 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-16049174