Detalhe da pesquisa
1.
In Vitro and In Vivo Properties of CUO246, a Novel Bacterial DNA Gyrase/Topoisomerase IV Inhibitor.
Antimicrob Agents Chemother
; 66(12): e0092122, 2022 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36448795
2.
Characterization of an Acinetobacter baumannii lptD Deletion Strain: Permeability Defects and Response to Inhibition of Lipopolysaccharide and Fatty Acid Biosynthesis.
J Bacteriol
; 198(4): 731-41, 2015 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26668262
3.
Synthesis of ciprofloxacin dimers for evaluation of bacterial permeability in atypical chemical space.
Bioorg Med Chem Lett
; 25(17): 3468-75, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26189081
4.
Effects of a defective endoplasmic reticulum-associated degradation pathway on the stress response, virulence, and antifungal drug susceptibility of the mold pathogen Aspergillus fumigatus.
Eukaryot Cell
; 12(4): 512-9, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23355008
5.
Identification and evaluation of novel acetolactate synthase inhibitors as antifungal agents.
Antimicrob Agents Chemother
; 57(5): 2272-80, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23478965
6.
HacA-independent functions of the ER stress sensor IreA synergize with the canonical UPR to influence virulence traits in Aspergillus fumigatus.
PLoS Pathog
; 7(10): e1002330, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22028661
7.
Divergent Protein Kinase A isoforms co-ordinately regulate conidial germination, carbohydrate metabolism and virulence in Aspergillus fumigatus.
Mol Microbiol
; 79(4): 1045-62, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21210869
8.
An integrated approach for identification and target validation of antifungal compounds active against Erg11p.
Antimicrob Agents Chemother
; 56(8): 4233-40, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22615293
9.
A role for the unfolded protein response (UPR) in virulence and antifungal susceptibility in Aspergillus fumigatus.
PLoS Pathog
; 5(1): e1000258, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19132084
10.
Secretion stress and antifungal resistance: an Achilles' heel of Aspergillus fumigatus?
Med Mycol
; 49 Suppl 1: S101-6, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-20608779
11.
Discovery and Optimization of DNA Gyrase and Topoisomerase IV Inhibitors with Potent Activity against Fluoroquinolone-Resistant Gram-Positive Bacteria.
J Med Chem
; 64(9): 6329-6357, 2021 05 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33929852
12.
Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria.
J Med Chem
; 63(14): 7773-7816, 2020 07 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32634310
13.
Impaired ribosome biogenesis disrupts the integration between morphogenesis and nuclear duplication during the germination of Aspergillus fumigatus.
Eukaryot Cell
; 7(4): 575-83, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18296619
14.
Unexpected link between metal ion deficiency and autophagy in Aspergillus fumigatus.
Eukaryot Cell
; 6(12): 2437-47, 2007 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17921348
15.
A pathway-directed positive growth restoration assay to facilitate the discovery of lipid A and fatty acid biosynthesis inhibitors in Acinetobacter baumannii.
PLoS One
; 13(3): e0193851, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29505586
16.
Interplay of Klebsiella pneumoniae fabZ and lpxC Mutations Leads to LpxC Inhibitor-Dependent Growth Resulting from Loss of Membrane Homeostasis.
mSphere
; 3(5)2018 10 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-30381354
17.
LpxK Is Essential for Growth of Acinetobacter baumannii ATCC 19606: Relationship to Toxic Accumulation of Lipid A Pathway Intermediates.
mSphere
; 2(4)2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28815210
18.
A Fluorescence-Based High-Throughput Screening Assay to Identify Growth Inhibitors of the Pathogenic Fungus Aspergillus fumigatus.
Methods Mol Biol
; 1439: 171-9, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27316995
19.
Toxic Accumulation of LPS Pathway Intermediates Underlies the Requirement of LpxH for Growth of Acinetobacter baumannii ATCC 19606.
PLoS One
; 11(8): e0160918, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27526195
20.
The virulence of the opportunistic fungal pathogen Aspergillus fumigatus requires cooperation between the endoplasmic reticulum-associated degradation pathway (ERAD) and the unfolded protein response (UPR).
Virulence
; 2(1): 12-21, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21217201