Detalhe da pesquisa
1.
Elevated In Vitro Kinase Activity in Peripheral Blood Mononuclear Cells of Leucine-Rich Repeat Kinase 2 G2019S Carriers: A Novel Enzyme-Linked Immunosorbent Assay-Based Method.
Mov Disord
; 35(11): 2095-2100, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32652692
2.
Kinase activity of mutant LRRK2 manifests differently in hetero-dimeric vs. homo-dimeric complexes.
Biochem J
; 476(3): 559-579, 2019 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30670570
3.
Nurr1:RXRα heterodimer activation as monotherapy for Parkinson's disease.
Proc Natl Acad Sci U S A
; 114(15): 3999-4004, 2017 04 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28348207
4.
P62/SQSTM1 is a novel leucine-rich repeat kinase 2 (LRRK2) substrate that enhances neuronal toxicity.
Biochem J
; 475(7): 1271-1293, 2018 04 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29519959
5.
Insights into the Influence of Specific Splicing Events on the Structural Organization of LRRK2.
Int J Mol Sci
; 19(9)2018 Sep 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-30223621
6.
Neuronal death signaling pathways triggered by mutant LRRK2.
Biochem Soc Trans
; 45(1): 123-129, 2017 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28202665
7.
Is spinal muscular atrophy a disease of the motor neurons only: pathogenesis and therapeutic implications?
Cell Mol Life Sci
; 73(5): 1003-20, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26681261
8.
LRRK2 Parkinson disease mutations enhance its microtubule association.
Hum Mol Genet
; 21(4): 890-9, 2012 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22080837
9.
The neurobiology of LRRK2 and its role in the pathogenesis of Parkinson's disease.
Neurochem Res
; 39(3): 576-92, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-23729298
10.
Perspective on the current state of the LRRK2 field.
NPJ Parkinsons Dis
; 9(1): 104, 2023 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37393318
11.
Doubly Constrained C-terminal of Roc (COR) Domain-Derived Peptides Inhibit Leucine-Rich Repeat Kinase 2 (LRRK2) Dimerization.
ACS Chem Neurosci
; 14(11): 1971-1980, 2023 06 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37200505
12.
Longitudinal transcriptomic analysis of mouse sciatic nerve reveals pathways associated with age-related muscle pathology.
J Cachexia Sarcopenia Muscle
; 14(3): 1322-1336, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36905126
13.
Distinct profiles of LRRK2 activation and Rab GTPase phosphorylation in clinical samples from different PD cohorts.
NPJ Parkinsons Dis
; 8(1): 73, 2022 Jun 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35676398
14.
LRRK2 kinase activity regulates GCase level and enzymatic activity differently depending on cell type in Parkinson's disease.
NPJ Parkinsons Dis
; 8(1): 92, 2022 Jul 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35853899
15.
Targeted disruption of neuronal 19S proteasome subunits induces the formation of ubiquitinated inclusions in the absence of cell death.
J Neurochem
; 119(3): 630-43, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21883213
16.
Defining (and blocking) neuronal death in Parkinson's disease: Does it matter what we call it?
Brain Res
; 1771: 147639, 2021 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34492263
17.
Allosteric Inhibition of Parkinson's-Linked LRRK2 by Constrained Peptides.
ACS Chem Biol
; 16(11): 2326-2338, 2021 11 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34496561
18.
The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration.
J Neurosci
; 29(4): 1011-6, 2009 Jan 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-19176810
19.
The Future of Targeted Gene-Based Treatment Strategies and Biomarkers in Parkinson's Disease.
Biomolecules
; 10(6)2020 06 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-32560161
20.
The Current State-of-the Art of LRRK2-Based Biomarker Assay Development in Parkinson's Disease.
Front Neurosci
; 14: 865, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33013290