Detalhe da pesquisa
1.
CD95-Mediated Calcium Signaling Promotes T Helper 17 Trafficking to Inflamed Organs in Lupus-Prone Mice.
Immunity
; 45(1): 209-23, 2016 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-27438772
2.
Metabolic disposition of H3B-8800, an orally available small-molecule splicing modulator, in rats, monkeys, and humans.
Xenobiotica
; 50(9): 1101-1114, 2020 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-31902291
3.
A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models.
Nat Chem Biol
; 11(6): 432-7, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25915199
4.
Physiologically Based Pharmacokinetic Modeling in Pediatric Oncology Drug Development.
Drug Metab Dispos
; 44(7): 934-43, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-26936973
5.
Species differences in metabolism of EPZ015666, an oxetane-containing protein arginine methyltransferase-5 (PRMT5) inhibitor.
Xenobiotica
; 46(3): 268-77, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26294260
6.
Structural and Kinetic Characterization of a Novel N-acetylated Aliphatic Amine Metabolite of the PRMT Inhibitor, EPZ011652.
Drug Metab Dispos
; 43(7): 936-43, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25887455
7.
Preclinical profile of BI 224436, a novel HIV-1 non-catalytic-site integrase inhibitor.
Antimicrob Agents Chemother
; 58(6): 3233-44, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24663024
8.
Structure-based design of novel HCV NS5B thumb pocket 2 allosteric inhibitors with submicromolar gt1 replicon potency: discovery of a quinazolinone chemotype.
Bioorg Med Chem Lett
; 23(14): 4132-40, 2013 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23768906
9.
A membrane vesicle-based assay to enable prediction of human biliary excretion.
Xenobiotica
; 43(10): 915-9, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23402371
10.
A simplified approach to predict CYP3A-mediated drug-drug interactions at early drug discovery: validation with clinical data.
Xenobiotica
; 43(7): 592-7, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23244592
11.
Assessment of CYP3A-mediated drug-drug interaction potential for victim drugs using an in vivo rat model.
Biopharm Drug Dispos
; 34(7): 396-401, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23873286
12.
A comprehensive evaluation in clinic and physiologically-based pharmacokinetic modeling and simulation to confirm lack of cytochrome P450-mediated drug-drug interaction potential for pomotrelvir.
CPT Pharmacometrics Syst Pharmacol
; 12(10): 1553-1564, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37614073
13.
Discovery of KB-0742, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of CDK9 for MYC-Dependent Cancers.
J Med Chem
; 66(23): 15629-15647, 2023 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37967851
14.
A high throughput in vitro mrp2 assay to predict in vivo biliary excretion.
Xenobiotica
; 42(2): 157-63, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21961530
15.
Nonclinical pharmacokinetics and in vitro metabolism of H3B-6545, a novel selective ERα covalent antagonist (SERCA).
Cancer Chemother Pharmacol
; 83(1): 151-160, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30386887
16.
Effect of a high-fat meal on the relative bioavailability of H3B-6527, a novel FGFR4 inhibitor, in healthy volunteers.
Cancer Chemother Pharmacol
; 83(1): 91-96, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30368584
17.
Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss.
Cancer Cell
; 36(1): 100-114.e25, 2019 07 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31257072
18.
Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERαWT and ERαMUT Breast Cancer.
Cancer Discov
; 8(9): 1176-1193, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29991605
19.
Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation.
PLoS One
; 13(6): e0197372, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29856759
20.
H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma.
Cancer Res
; 77(24): 6999-7013, 2017 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29247039