RESUMO
Pilomatrixoma of the eyelid is extremely rare in middle age and rarely develops into a large tumor. A 45-year-old female developed a painless, progressive swelling (3.0 cm x 2.0 cm) of the left upper eyelid over a period of two years. Overlying skin was normal in color and texture. A differential diagnosis of dermoid, epidermoid cyst, chalazion and basal cell carcinoma was made. An excisional biopsy was performed. A diagnosis of pilomatrixoma was made on histopathological features (dystrophic calcification of matrix with keratin and foreign body granulomatous reaction, basaloid cells and shadow cells/ghost cells). It also comprises ossification apart from the usual calcification. This is a report of an unusually large ossifying pilomatrixoma in left upper eyelid of a middle-aged woman. The patient should be followed up at regular intervals to rule out any recurrence or malignant transformation.
Assuntos
Neoplasias Palpebrais/patologia , Doenças do Cabelo/patologia , Ossificação Heterotópica/patologia , Pilomatrixoma/patologia , Neoplasias Cutâneas/patologia , Diagnóstico Diferencial , Neoplasias Palpebrais/cirurgia , Feminino , Doenças do Cabelo/cirurgia , Humanos , Pessoa de Meia-Idade , Ossificação Heterotópica/cirurgia , Pilomatrixoma/cirurgia , Neoplasias Cutâneas/cirurgiaRESUMO
Xeroderma pigmentosum (XP) is an autosomal recessive genetic disorder of DNA repair in which the body's normal ability to repair damage caused by ultraviolet light is deficient. This leads to a 1000-fold increased risk of cutaneous and ocular neoplasms. Ocular neoplasms occurring in XP in order of frequency are squamous cell carcinoma, basal cell carcinoma and melanoma. Malignant melanomas occur at an early age in patients with XP. We report a case of XP with massive orbital melanoma in an eight-year-old boy which is unique due to its amelanotic presentation confirmed histopathologically.
Assuntos
Melanoma Amelanótico/complicações , Órbita , Neoplasias Cutâneas/complicações , Xeroderma Pigmentoso/complicações , Criança , Diagnóstico Diferencial , Humanos , Masculino , Melanoma Amelanótico/patologia , Melanoma Amelanótico/cirurgia , Procedimentos Cirúrgicos Oftalmológicos/métodos , Neoplasias Cutâneas/patologia , Neoplasias Cutâneas/cirurgia , Xeroderma Pigmentoso/patologia , Xeroderma Pigmentoso/cirurgiaRESUMO
Pilomatrixoma of the eyelid is extremely rare in middle age and rarely develops into a large tumor. A 45-year-old female developed a painless, progressive swelling (3.0 cm x 2.0 cm) of the left upper eyelid over a period of two years. Overlying skin was normal in color and texture. A differential diagnosis of dermoid, epidermoid cyst, chalazion and basal cell carcinoma was made. An excisional biopsy was performed. A diagnosis of pilomatrixoma was made on histopathological features (dystrophic calcification of matrix with keratin and foreign body granulomatous reaction, basaloid cells and shadow cells/ghost cells). It also comprises ossification apart from the usual calcification. This is a report of an unusually large ossifying pilomatrixoma in left upper eyelid of a middle-aged woman. The patient should be followed up at regular intervals to rule out any recurrence or malignant transformation.
RESUMO
Xeroderma pigmentosum (XP) is an autosomal recessive genetic disorder of DNA repair in which the body's normal ability to repair damage caused by ultraviolet light is deficient. This leads to a 1000-fold increased risk of cutaneous and ocular neoplasms. Ocular neoplasms occurring in XP in order of frequency are squamous cell carcinoma, basal cell carcinoma and melanoma. Malignant melanomas occur at an early age in patients with XP. We report a case of XP with massive orbital melanoma in an eight-year-old boy which is unique due to its amelanotic presentation confirmed histopathologically.