Detalhe da pesquisa
1.
Fatty acid binding to the human transport proteins FABP3, FABP4, and FABP5 from a Ligand's perspective.
J Biol Chem
; 300(6): 107396, 2024 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38777142
2.
Direct GPCR-EGFR interaction enables synergistic membrane-to-nucleus information transfer.
Cell Mol Life Sci
; 81(1): 272, 2024 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38900158
3.
Exploring Aromatic Cage Flexibility Using Cosolvent Molecular Dynamics SimulationsâAn In-Silico Case Study of Tudor Domains.
J Chem Inf Model
; 64(11): 4553-4569, 2024 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38771194
4.
Comparative Structure-Based Virtual Screening Utilizing Optimized AlphaFold Model Identifies Selective HDAC11 Inhibitor.
Int J Mol Sci
; 25(2)2024 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38279359
5.
First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement.
Chembiochem
; 23(14): e202200180, 2022 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35608330
6.
Design, Synthesis and Biological Characterization of Histone Deacetylase 8 (HDAC8) Proteolysis Targeting Chimeras (PROTACs) with Anti-Neuroblastoma Activity.
Int J Mol Sci
; 23(14)2022 Jul 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35886887
7.
Docking, Binding Free Energy Calculations and In Vitro Characterization of Pyrazine Linked 2-Aminobenzamides as Novel Class I Histone Deacetylase (HDAC) Inhibitors.
Molecules
; 27(8)2022 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35458724
8.
Exploring aromatic cage flexibility of the histone methyllysine reader protein Spindlin1 and its impact on binding mode prediction: an in silico study.
J Comput Aided Mol Des
; 35(6): 695-706, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34081238
9.
Evaluation of γ-carboline-phenothiazine conjugates as simultaneous NMDA receptor blockers and cholinesterase inhibitors.
Bioorg Med Chem
; 46: 116355, 2021 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34391122
10.
Structure-Based Design, Docking and Binding Free Energy Calculations of A366 Derivatives as Spindlin1 Inhibitors.
Int J Mol Sci
; 22(11)2021 May 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-34072837
11.
Synthesis, Molecular Docking and Biological Characterization of Pyrazine Linked 2-Aminobenzamides as New Class I Selective Histone Deacetylase (HDAC) Inhibitors with Anti-Leukemic Activity.
Int J Mol Sci
; 23(1)2021 Dec 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-35008795
12.
Binding Free Energy (BFE) Calculations and Quantitative Structure-Activity Relationship (QSAR) Analysis of Schistosoma mansoni Histone Deacetylase 8 (smHDAC8) Inhibitors.
Molecules
; 26(9)2021 Apr 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-33925246
13.
HaloTag-Targeted Sirtuin-Rearranging Ligand (SirReal) for the Development of Proteolysis-Targeting Chimeras (PROTACs) against the Lysine Deacetylase Sirtuin 2 (Sirt2)*.
Chembiochem
; 21(23): 3371-3376, 2020 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32672888
14.
Impact of hydroxy moieties at the benzo[7]annulene ring system of GluN2B ligands: Design, synthesis and biological evaluation.
Bioorg Med Chem
; 27(23): 115146, 2019 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31648876
15.
The Current State of NAD+ -Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets.
Med Res Rev
; 38(1): 147-200, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28094444
16.
Opening the Selectivity Pocket in the Human Lysine Deacetylase Sirtuin2 - New Opportunities, New Questions.
Chem Rec
; 18(12): 1701-1707, 2018 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-29931800
17.
A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing.
Molecules
; 23(3)2018 Mar 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29498707
18.
Muscle Carnitine Palmitoyltransferase II Deficiency: A Review of Enzymatic Controversy and Clinical Features.
Int J Mol Sci
; 18(1)2017 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28054946
19.
Stereospecific capillary electrophoresis assays using pentapeptide substrates for the study of Aspergillus nidulans methionine sulfoxide reductase A and mutant enzymes.
Electrophoresis
; 37(14): 2083-90, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27145186
20.
Benzo[7]annulene-based GluN2B selective NMDA receptor antagonists: Surprising effect of a nitro group in 2-position.
Bioorg Med Chem Lett
; 25(24): 5748-51, 2015 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26531150