Detalhe da pesquisa
1.
Deciphering the Exact Sequence of Endogenous Soluble B Cell Maturation Antigen and Unbiased Quantitation in Multiple Myeloma Patient Samples by LC-MS.
Clin Chem
; 70(1): 339-349, 2024 01 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38175591
2.
Modeling the CRL4A ligase complex to predict target protein ubiquitination induced by cereblon-recruiting PROTACs.
J Biol Chem
; 298(4): 101653, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35101445
3.
Absorption, Distribution, Metabolism, and Excretion of [14C]-Sotorasib in Rats and Dogs: Interspecies Differences in Absorption, Protein Conjugation and Metabolism.
Drug Metab Dispos
; 50(5): 600-612, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35153196
4.
Universal Automated Immunoaffinity Purification-CE-MS Platform for Accelerating Next Generation Biologic Design.
Anal Chem
; 93(13): 5562-5569, 2021 04 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33764735
5.
Strain-Dependent Variability of Early Discovery Small Molecule Pharmacokinetics in Mice: Does Strain Matter?
Drug Metab Dispos
; 48(8): 613-621, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32474442
6.
Mechanistic Studies of Cytochrome P450 3A4 Time-Dependent Inhibition Using Two Cysteine-Targeting Electrophiles.
Drug Metab Dispos
; 48(6): 508-514, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32193357
7.
Pharmacokinetic and Drug Metabolism Properties of Novel Therapeutic Modalities.
Drug Metab Dispos
; 47(10): 1097-1099, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31399505
8.
Plasma and Liver Protein Binding of N-Acetylgalactosamine-Conjugated Small Interfering RNA.
Drug Metab Dispos
; 47(10): 1174-1182, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31097425
9.
Immunoaffinity capture coupled with capillary electrophoresis - mass spectrometry to study therapeutic protein stability in vivo.
Anal Biochem
; 539: 118-126, 2017 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29029979
10.
Altering Antibody-Drug Conjugate Binding to the Neonatal Fc Receptor Impacts Efficacy and Tolerability.
Mol Pharm
; 13(7): 2387-96, 2016 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27248573
11.
Intracellular Catabolism of an Antibody Drug Conjugate with a Noncleavable Linker.
Drug Metab Dispos
; 43(9): 1341-4, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26101225
12.
Characterization of ritonavir-mediated inactivation of cytochrome P450 3A4.
Mol Pharmacol
; 86(6): 665-74, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25274602
13.
Characterization of the active site properties of CYP4F12.
Drug Metab Dispos
; 42(10): 1698-707, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25074871
14.
Evaluation of near infrared fluorescent labeling of monoclonal antibodies as a tool for tissue distribution.
Drug Metab Dispos
; 42(11): 1906-13, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25209366
15.
Preclinical development and phase 1 trial of a novel siRNA targeting lipoprotein(a).
Nat Med
; 28(1): 96-103, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35027752
16.
Multienzyme Kinetics and Sequential Metabolism.
Methods Mol Biol
; 2342: 89-112, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34272692
17.
Case Study 12: Roadmap to Quantifying Ago2-Mediated siRNA Metabolic Activation Kinetics.
Methods Mol Biol
; 2342: 825-841, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34272719
18.
Emerging siRNA Design Principles and Consequences for Biotransformation and Disposition in Drug Development.
J Med Chem
; 63(12): 6407-6422, 2020 06 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32352779
19.
POE Immunoassay: Plate-based oligonucleotide electro-chemiluminescent immunoassay for the quantification of nucleic acids in biological matrices.
Sci Rep
; 10(1): 10425, 2020 06 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-32591626
20.
Introducing an In Vitro Liver Stability Assay Capable of Predicting the In Vivo Pharmacodynamic Efficacy of siRNAs for IVIVC.
Mol Ther Nucleic Acids
; 21: 725-736, 2020 Sep 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32771924