RESUMO
INTRODUCTION AND OBJECTIVES: There is scarce information on patients with single ventricle physiology (SVP) and restricted pulmonary flow not undergoing Fontan circulation. This study aimed to compare survival and cardiovascular events in these patients according to the type of palliation. METHODS: SVP patient data were obtained from the databases of the adult congenital heart disease units of 7 centers. Patients completing Fontan circulation or developing Eisenmenger syndrome were excluded. Three groups were created according to the source of pulmonary flow: G1 (restrictive pulmonary forward flow), G2 (cavopulmonary shunt), and G3 (aortopulmonary shunts±cavopulmonary shunt). The primary endpoint was death. RESULTS: We identified 120 patients. Mean age at the first visit was 32.2 years. Mean follow-up was 7.1 years. Fifty-five patients (45.8%) were assigned to G1, 30 (25%) to G2, and 35 (29.2%) to G3. Patients in G3 had worse renal function, functional class, and ejection fraction at the first visit and a more marked ejection fraction decline during follow-up, especially when compared with G1. Twenty-four patients (20%) died, 38 (31.7%) were admitted for heart failure, and 21 (17.5%) had atrial flutter/fibrillation during follow-up. These events were more frequent in G3 and significant differences were found compared with G1 in terms of death (HR, 2.9; 95%CI, 1.14-7.37; P=.026) and atrial flutter/fibrillation (HR, 2.9; 95%CI, 1.11-7.68; P=.037). CONCLUSIONS: The type of palliation in patients with SVP and restricted pulmonary flow not undergoing Fontan palliation identifies distinct profiles. Patients palliated with aortopulmonary shunts have an overall worse prognosis with higher morbidity and mortality.
Assuntos
Fibrilação Atrial , Flutter Atrial , Técnica de Fontan , Cardiopatias Congênitas , Coração Univentricular , Humanos , Adulto , Coração Univentricular/cirurgia , Cardiopatias Congênitas/cirurgia , Ventrículos do Coração/cirurgia , Resultado do Tratamento , Estudos Retrospectivos , Artéria Pulmonar/cirurgiaRESUMO
BACKGROUND: To describe long-term survival and cardiovascular events in adult patients with single ventricle physiology (SVP) without Fontan palliation, focusing on predictors of mortality and comparing groups according to their cardiovascular physiology. METHODS: Multicentre observational and retrospective study including adult patients with SVP without Fontan palliation since their first adult clinic visit. The cohort was subdivided into 3 groups: Eisenmenger, restricted pulmonary flow, and aortopulmonary shunt. Death was considered as the main end point. Other clinical outcomes occurring during follow-up were considered as secondary end points. RESULTS: A total of 146 patients, mean age 32.5 ± 11.1 years, were analysed. Over a mean follow-up of 7.3 ± 4.1 years, 33 patients (22.6%) died. Survival was 86% and 74% at 5 and 10 years, respectively. Right ventricular morphology was not associated with higher mortality. Four variables at baseline were related to a higher mortality: at least moderate atrioventricular valve regurgitation, platelet count < 150 × 103/mm3, GFR < 60 mL/min/1.73 m2, and QRS > 120 ms). A total of 34.2% of patients were admitted to the hospital due to heart failure, and 7.5% received a heart transplant. Other cardiovascular outcomes were also frequent: atrial arrhythmias in 19.2%, stroke in 15.1%, and pacemaker/implantable cardioverter-defibrillator in 6.2%/2.7%. CONCLUSIONS: Adult patients with SVP who had not undergone Fontan exhibit a high mortality rate and frequent major cardiovascular events. At least moderate atrioventricular valve regurgitation, thrombocytopenia, renal dysfunction, and QRS duration > 120 ms at baseline visit allow identification of a cohort of patients at higher risk of mortality.
Assuntos
Técnica de Fontan , Cardiopatias Congênitas , Adulto , Arritmias Cardíacas , Cardiopatias Congênitas/cirurgia , Ventrículos do Coração/cirurgia , Humanos , Estudos Retrospectivos , Resultado do TratamentoRESUMO
Transesophageal echocardiography (TEE) with agitated saline contrast is the most sensitive tool for diagnosing patent foramen ovale (PFO), but false positives can result. We report a patient who underwent a TEE during the study of a cryptogenic stroke. Contrast appeared in the left atrium with the Valsalva maneuver. However, the contrast exit site was not identified, and contrast continued to appear with Valsalva once the saline microbubbles had disappeared. Combined with the contrast characteristics, this suggested a spontaneous contrast phenomenon rather than a PFO. This phenomenon must be kept in mind to avoid overdiagnosing PFO.
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Artefatos , Ecocardiografia/métodos , Forame Oval Patente/diagnóstico por imagem , Adulto , Meios de Contraste , Reações Falso-Positivas , Humanos , Masculino , Manobra de ValsalvaRESUMO
Few data are known about the effects of sleep-related breathing disorders (SRBD) on the cardiovascular system in adolescents. Forty healthy adolescents (mean age, 13.7 +/- 1.6 years) answered a questionnaire regarding symptoms of sleep-related breathing disorders (SRBD) and underwent a cardiorespiratory polygraphy and echocardiography. Echocardiographic data in snorers with polygraphic abnormalities suggestive of SRBD (positive group, n = 29) were compared with the results in nonsnorers without polygraphic abnormalities (n = 11) who were included in the control group. Ventricular dimensions and indices of left ventricular systolic function were within normal limits and were not significantly different between the two groups. Indices of left ventricular diastolic function were also within normal limits, but isovolumetric relaxation time (IVRT) was significantly longer among the positive group (72.5 +/- 8.4 msec) than among the controls (65.1 +/- 7.9 msec) (P = 0.018). Multiple regression analysis showed that posterior wall thickness was predicted by a model that included cardiac events related with respiratory events and/or desaturations, and respiratory disturbance index (RDI) in supine position. Deceleration of early diastolic flow was predicted by RDI, percentage of total recording time with SaO(2) < 90% (CT(90)), and age; the variability of isovolumetric relaxation time was predicted by a model that included RDI in supine position. We found a significant relationship between polygraphic parameters suggestive of SRBD and echocardiographic measurements of ventricular dimensions and diastolic function. Also, echocardiographic parameters suggestive of some degree of left ventricular diastolic dysfunction were found in snoring adolescents with polygraphic abnormalities.
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Ecocardiografia Doppler , Polissonografia , Síndromes da Apneia do Sono/diagnóstico por imagem , Síndromes da Apneia do Sono/epidemiologia , Disfunção Ventricular Esquerda/diagnóstico por imagem , Adolescente , Distribuição por Idade , Estudos de Casos e Controles , Criança , Feminino , Humanos , Incidência , Masculino , Análise Multivariada , Probabilidade , Prognóstico , Valores de Referência , Análise de Regressão , Medição de Risco , Sensibilidade e Especificidade , Índice de Gravidade de Doença , Distribuição por Sexo , Espanha/epidemiologia , Inquéritos e Questionários , Disfunção Ventricular Esquerda/epidemiologiaRESUMO
Introducción y objetivos: La información sobre pacientes con fisiología univentricular (FU) y flujo pulmonar restrictivo no sometidos a cirugía de Fontan es escasa. El objetivo de este estudio es comparar la supervivencia y los eventos cardiovasculares en estos pacientes según el tipo de paliación.MétodosLos datos de pacientes con FU se obtuvieron de las bases de datos de 7 centros con unidades de cardiopatías congénitas del adulto. Se excluyó a los pacientes que completaron la circulación de Fontan o desarrollaron un síndrome de Eisenmenger. Se crearon 3 grupos según la fuente de flujo pulmonar: G1, flujo anterógrado pulmonar restrictivo; G2, shunt cavopulmonar, y G3, shunt aortopulmonar±shunt cavopulmonar. El objetivo principal fue la muerte.ResultadosSe identificó a 120 pacientes. La media de edad en la primera visita fue 32,2 años. El seguimiento medio fue de 7,1 años. Se asignó a 55 pacientes (45,8%) al G1, 30 (25%) al G2 y 35 (29,2%) al G3. Los pacientes del G3 tenían peores función renal, clase funcional y fracción de eyección en la primera visita y mostraron una disminución más marcada de la fracción de eyección durante el seguimiento, especialmente en comparación con el G1. Veinticuatro pacientes (20%) fallecieron, 38 (31,7%) ingresaron por insuficiencia cardiaca y 21 (17,5%) presentaron aleteo/fibrilación auricular durante el seguimiento. Estos eventos fueron más frecuentes en el G3 y al compararlos con los del G1 se encontraron diferencias significativas en muerte (HR=2,9; IC95%, 1,14-7,37; p=0,026) y aleteo/fibrilación auricular (HR=2,9; IC95%, 1,11-7,68; p=0,037).ConclusionesEl tipo de paliación de los pacientes con FU y flujo pulmonar restrictivo no sometidos a cirugía de Fontan identifica distintos perfiles. Los pacientes paliados con derivaciones aortopulmonares presentan un peor pronóstico, con más morbilidad y mortalidad. (AU)
Introduction and objectives: There is scarce information on patients with single ventricle physiology (SVP) and restricted pulmonary flow not undergoing Fontan circulation. This study aimed to compare survival and cardiovascular events in these patients according to the type of palliation.MethodsSVP patient data were obtained from the databases of the adult congenital heart disease units of 7 centers. Patients completing Fontan circulation or developing Eisenmenger syndrome were excluded. Three groups were created according to the source of pulmonary flow: G1 (restrictive pulmonary forward flow), G2 (cavopulmonary shunt), and G3 (aortopulmonary shunts±cavopulmonary shunt). The primary endpoint was death.ResultsWe identified 120 patients. Mean age at the first visit was 32.2 years. Mean follow-up was 7.1 years. Fifty-five patients (45.8%) were assigned to G1, 30 (25%) to G2, and 35 (29.2%) to G3. Patients in G3 had worse renal function, functional class, and ejection fraction at the first visit and a more marked ejection fraction decline during follow-up, especially when compared with G1. Twenty-four patients (20%) died, 38 (31.7%) were admitted for heart failure, and 21 (17.5%) had atrial flutter/fibrillation during follow-up. These events were more frequent in G3 and significant differences were found compared with G1 in terms of death (HR, 2.9; 95%CI, 1.14-7.37; P=.026) and atrial flutter/fibrillation (HR, 2.9; 95%CI, 1.11-7.68; P=.037).ConclusionsThe type of palliation in patients with SVP and restricted pulmonary flow not undergoing Fontan palliation identifies distinct profiles. Patients palliated with aortopulmonary shunts have an overall worse prognosis with higher morbidity and mortality. (AU)
Assuntos
Humanos , Cardiopatias Congênitas , Técnica de Fontan , Complexo de Eisenmenger , CardiologiaRESUMO
INTRODUCTION AND OBJECTIVES: To assess the value of N-terminal fragment of brain natriuretic peptide (NT-proBNP) measurement and echocardiography for predicting ventricular remodeling after myocardial infarction and to investigate relationships between the NT-proBNP level and echocardiographic parameters at discharge and in the medium term. METHODS: The study involved 159 patients with myocardial infarction treated by primary coronary angioplasty. The NT-proBNP level was measured on admission, at discharge and after 6 months. Echocardiography was performed at discharge and after 6 months. RESULTS: Overall, 31 patients (19.5%) demonstrated remodeling. At discharge, the variables associated with remodeling were: mitral inflow E-wave-to-A-wave velocity ratio (E/A), systolic mitral annulus velocity (Sm), early diastolic mitral annulus velocity (Em), the mitral inflow E wave to early diastolic mitral annulus velocity ratio (E/ Em), left atrial volume (LAV), left ventricular end-systolic volume (LVESV), left ventricular end-diastolic volume (LVEDV), and discharge NT-proBNP level. Only E/Em was an independent predictor of ventricular remodeling (odds ratio [OR]=1.143; 95% confidence interval [CI], 1.039-1.258; P=.006). At discharge, correlations were observed between the NT-proBNP level and LVEDV, LVESV, ejection fraction (EF) and E/Em. At 6 months, correlations with ventricular volumes and EF were unchanged, the correlation with E/Em was better (r=0.47 vs. r=0.69), and a modest correlation with LAV developed (r=0.43; P=.001). CONCLUSIONS: The E/Em ratio was the best echocardiographic predictor of left ventricular remodeling after myocardial infarction. The NT-proBNP level had no additional predictive value over echocardiography. Correlations between the NT-proBNP level and ventricular volumes and EF at discharge and 6 months were similar, while correlations with E/Em and LAV were better at 6 months.
Assuntos
Angioplastia , Infarto do Miocárdio/sangue , Infarto do Miocárdio/diagnóstico por imagem , Peptídeo Natriurético Encefálico/sangue , Fragmentos de Peptídeos/sangue , Remodelação Ventricular , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Infarto do Miocárdio/fisiopatologia , Infarto do Miocárdio/terapia , Valor Preditivo dos Testes , Estudos Prospectivos , UltrassonografiaAssuntos
Ecocardiografia Transesofagiana/métodos , Endocardite Bacteriana/complicações , Insuficiência da Valva Mitral/diagnóstico por imagem , Insuficiência da Valva Mitral/etiologia , Adulto , Idoso , Angiografia Coronária , Ecocardiografia Tridimensional/métodos , Endocardite Bacteriana/cirurgia , Enterococcus faecalis , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Insuficiência da Valva Mitral/cirurgia , Infecções Estreptocócicas/complicações , Streptococcus mitisAssuntos
Coração Triatriado , Idoso , Coração Triatriado/diagnóstico por imagem , Feminino , Humanos , UltrassonografiaRESUMO
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Humanos , Masculino , Pessoa de Meia-Idade , Divertículo/complicações , Divertículo/diagnóstico , Meios de Contraste , Ecocardiografia/métodos , Ecocardiografia , Fibrilação Atrial/complicações , Fibrilação Atrial/diagnóstico , Ecocardiografia Transesofagiana/tendências , Ecocardiografia Transesofagiana , Divertículo/fisiopatologia , Divertículo , Fibrilação Atrial , Vasos Coronários/patologia , Vasos Coronários , Ecocardiografia Transesofagiana/métodosRESUMO
No disponible
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Humanos , Feminino , Adulto , Pessoa de Meia-Idade , Endocardite , Ecocardiografia Transesofagiana/tendências , Ecocardiografia Transesofagiana , Ecocardiografia Tridimensional/métodos , Ecocardiografia Tridimensional , Insuficiência da Valva Mitral , Enterococcus faecalis/isolamento & purificação , Endocardite/fisiopatologia , Ecocardiografia Tridimensional/instrumentação , Ecocardiografia Tridimensional/tendências , Imageamento Tridimensional/métodosRESUMO
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Humanos , Masculino , Feminino , Obstrução do Fluxo Ventricular Externo/complicações , Obstrução do Fluxo Ventricular Externo/diagnóstico , Obstrução do Fluxo Ventricular Externo/terapia , Taquicardia/complicações , Taquicardia/diagnóstico , TaquicardiaRESUMO
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Humanos , Feminino , Pessoa de Meia-Idade , Cardiopatias Congênitas/complicações , Cardiopatias Congênitas/diagnóstico , Ecocardiografia/métodos , Ecocardiografia , Estenose da Valva Aórtica/complicações , Estenose da Valva Aórtica/diagnóstico , Hipertensão/complicações , Cardiopatias Congênitas , Estenose da Valva Aórtica/fisiopatologia , Estenose da Valva AórticaRESUMO
Introducción y objetivos. Estudiar el valor del fragmento aminoterminal del péptido natriurético cerebral (NT-proBNP) y del ecocardiograma para predecir remodelado tras infarto y relacionar el NT-proBNP con el ecocardiograma al alta y en fase crónica. Métodos. Estudiamos a 159 pacientes con infarto tratados con angioplastia primaria. Se determinó el NT-pro-BNP al ingreso, al alta y al sexto mes. Se hizo ecocardiograma al alta y al sexto mes. Resultados. Treinta y un pacientes (19,5%) sufrieron remodelado. Al alta se asociaron con remodelado: el cociente entre velocidades E y A del llenado mitral (E/A), la velocidad sistólica del anillo mitral (Sm), la velocidad diastólica precoz del anillo mitral (Em), el cociente entre onda E del llenado mitral y velocidad diastólica precoz del anillo mitral (E/Em), el volumen auricular izquierdo (VAI), los volúmenes telediastólico (VTD) y telesistólico (VTS) ventriculares izquierdos y el NT-proBNP al alta. De ellas, sólo el E/Em fue predictor independiente de remodelado (odds ratio [OR] = 1,143; intervalo de confianza [IC] del 95%, 1,039-1,258; p = 0,006). Al alta, el NT-pro-BNP se correlacionó con el VTD, el VTS, la fracción de eyección (FE) y el E/Em. Al sexto mes, había similar correlación con volúmenes ventriculares y FE, mejoró la correlación con el E/Em (r = 0,47 frente a r = 0,69) y apareció correlación modesta con el VAI (r = 0,43; p = 0,001). Conclusiones. El cociente E/Em es el mejor predictor ecocardiográfico de remodelado tras infarto. El NT-pro-BNP pierde valor predictor al considerarlo junto con el ecocardiograma. El NT-proBNP se correlaciona igualmente con volúmenes ventriculares y FE al alta y al sexto mes, mientras que la correlación con el cociente E/Em y el VAI es más relevante al sexto mes (AU)
Introduction and objectives. To assess the value of N-terminal fragment of brain natriuretic peptide (NT-proBNP) measurement and echocardiography for predicting ventricular remodeling after myocardial infarction and to investigate relationships between the NT-proBNP level and echocardiographic parameters at discharge and in the medium term. Methods. The study involved 159 patients with myocardial infarction treated by primary coronary angioplasty. The NT-proBNP level was measured on admission, at discharge and after 6 months. Echocardiography was performed at discharge and after 6 months. Results. Overall, 31 patients (19.5%) demonstrated remodeling. At discharge, the variables associated with remodeling were: mitral inflow E-wave-to-A-wave velocity ratio (E/A), systolic mitral annulus velocity (Sm), early diastolic mitral annulus velocity (Em), the mitral inflow E wave to early diastolic mitral annulus velocity ratio (E/ Em), left atrial volume (LAV), left ventricular end-systolic volume (LVESV), left ventricular end-diastolic volume (LVEDV), and discharge NT-proBNP level. Only E/Em was an independent predictor of ventricular remodeling (odds ratio [OR]=1.143; 95% confidence interval [CI], 1.039-1.258; P=.006). At discharge, correlations were observed between the NT-proBNP level and LVEDV, LVESV, ejection fraction (EF) and E/Em. At 6 months, correlations with ventricular volumes and EF were unchanged, the correlation with E/Em was better (r=0.47 vs. r=0.69), and a modest correlation with LAV developed (r=0.43; P=.001). Conclusions. The E/Em ratio was the best echocardiographic predictor of left ventricular remodeling after myocardial infarction. The NT-proBNP level had no additional predictive value over echocardiography. Correlations between the NT-proBNP level and ventricular volumes and EF at discharge and 6 months were similar, while correlations with E/Em and LAV were better at 6 months (AU)
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Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Infarto do Miocárdio/epidemiologia , Angioplastia/métodos , Angioplastia/tendências , Natriuréticos/uso terapêutico , Imunoensaio/estatística & dados numéricos , Imunoensaio/tendências , Doenças Cardiovasculares/diagnóstico , Análise Multivariada , Ecocardiografia/métodos , Ecocardiografia , Pressão Sanguínea/fisiologia , Intervalos de Confiança , 28599RESUMO
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