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1.
Emerg Infect Dis ; 25(8)2019 08.
Artigo em Inglês | MEDLINE | ID: mdl-31310232

RESUMO

We report 7 cases of melioidosis in Colombia and comparision of 4 commercial systems for identifying Burkholderia pseudomallei. Phoenix systems were not a definitive method for identifying B. pseudomallei. For accurate identification, we recommend including this bacterium in the library databases of matrix-assisted laser desorption/ionization mass spectrometry systems in Latin America.


Assuntos
Burkholderia pseudomallei , Melioidose/diagnóstico , Melioidose/microbiologia , Antibacterianos/farmacologia , Antibacterianos/uso terapêutico , Burkholderia pseudomallei/classificação , Burkholderia pseudomallei/efeitos dos fármacos , Burkholderia pseudomallei/genética , Burkholderia pseudomallei/isolamento & purificação , Colômbia , DNA Espaçador Ribossômico , Humanos , Melioidose/tratamento farmacológico , Testes de Sensibilidade Microbiana , Técnicas de Diagnóstico Molecular , Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz , Resultado do Tratamento
3.
Biomedica ; 43(3): 323-329, 2023 09 30.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-37871571

RESUMO

Bacteremia by non-O1/non-O139 Vibrio cholerae is a rare entity associated with high mortality rates. We report a case of non-O1/non-O139 V. cholerae bacteremia confirmed by polymerase chain reaction and agglutination tests. The clinicoepidemiological characteristics and therapeutic options for this infection are also described.


La bacteriemia por V. cholerae no-O1/no-O139 es una entidad poco frecuente que se asocia con altas tasas de mortalidad. Reportamos un caso de bacteriemia por V. cholerae no-O1/no-O139 confirmado por reacción en cadena de la polimerasa (PCR) y test de aglutinación. Se describen además las características clínico-epidemiológicas y opciones terapéuticas para esta infección.


Assuntos
Bacteriemia , Vibrio cholerae não O1 , Humanos , Vibrio cholerae não O1/genética , Bacteriemia/diagnóstico , Reação em Cadeia da Polimerase
4.
J Fungi (Basel) ; 9(4)2023 Mar 31.
Artigo em Inglês | MEDLINE | ID: mdl-37108885

RESUMO

Candida auris has become a major health threat due to its transmissibility, multidrug resistance and severe outcomes. In a case-control design, 74 hospitalised patients with candidemia were enrolled. In total, 22 cases (29.7%) and 52 controls (C. albicans, 21.6%; C. parapsilosis, 21.6%; C. tropicalis, 21.6%; C. glabrata, 1.4%) were included and analysed in this study. Risk factors, clinical and microbiological characteristics and outcomes of patients with C. auris and non-auris Candida species (NACS) candidemia were compared. Previous fluconazole exposure was significantly higher in C. auris candidemia patients (OR 3.3; 1.15-9.5). Most C. auris isolates were resistant to fluconazole (86.3%) and amphotericin B (59%) whilst NACS isolates were generally susceptible. No isolates resistant to echinocandins were detected. The average time to start antifungal therapy was 3.6 days. Sixty-three (85.1%) patients received adequate antifungal therapy, without significant differences between the two groups. The crude mortality at 30 and 90 days of candidemia was up to 37.8% and 40.5%, respectively. However, there was no difference in mortality both at 30 and 90 days between the group with candidemia by C. auris (31.8%) and by NACS (42.3%) (OR 0.6; 95% IC 0.24-1.97) and 36.4% and 42.3% (0.77; 0.27-2.1), respectively. In this study, mortality due to candidemia between C. auris and NACS was similar. Appropriate antifungal therapy in both groups may have contributed to finding no differences in outcomes.

5.
Am J Trop Med Hyg ; 103(5): 1838-1840, 2020 11.
Artigo em Inglês | MEDLINE | ID: mdl-32748772

RESUMO

Burkholderia pseudomallei is an emerging pathogen in the Americas. Cases of mother-to-child transmission of B. pseudomallei are rare and probably occur by placental or perinatal infection. We report the first case of native gestational and neonatal melioidosis in the Western hemisphere. The isolated strains in the mother and newborn were confirmed by whole-genome sequencing and identified as a novel sequence type ST1748. The comparison of both genomes revealed a nucleotide similarity of 100%. Melioidosis should be considered within the differential diagnosis of febrile illness or pneumonia in pregnant women and newborns from endemic areas of the Americas.


Assuntos
Transmissão Vertical de Doenças Infecciosas , Melioidose/diagnóstico , Melioidose/transmissão , Antibacterianos , Burkholderia pseudomallei/genética , Burkholderia pseudomallei/isolamento & purificação , Colômbia/epidemiologia , Feminino , Genoma Bacteriano , Humanos , Recém-Nascido , Melioidose/tratamento farmacológico , Melioidose/epidemiologia , Gravidez , Adulto Jovem
6.
Biomedica ; 39: 10-18, 2019 05 01.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-31529845

RESUMO

Melioidosis is an infectious disease caused by Burkholderia pseudomallei whose clinical diagnosis can be difficult due not only to its varied clinical presentation but also to the difficulties in the microbiological diagnosis.Thus, it may be necessary to use molecular techniques for its proper identification once it is suspected. There are few antibiotics available for the treatment of this disease, which must be used over a long period of time. Although it is known to be endemic in Thailand, Malaysia, Singapore, Vietnam, and Australia, in Colombia there are few reported cases. We describe a case of melioidosis in the northern region of Colombia. Additionally, we review its clinical characteristics and treatment and we describe the local epidemiology of this disease.


La melioidosis es una enfermedad infecciosa causada por Burkholderia pseudomallei cuyo diagnóstico clínico puede ser difícil debido a su variada presentación clínica y a las dificultades del diagnóstico microbiológico, por lo cual pueden requerirse técnicas moleculares para su adecuada identificación una vez se sospecha su presencia. Son pocos los antibióticos disponibles para el tratamiento de esta enfermedad y, además, deben usarse durante un tiempo prolongado. Aunque se conoce por ser endémica en Tailandia, Malasia, Singapur, Vietnam y Australia, en Colombia se han reportado algunos pocos casos. Se presenta un caso de melioidosis en la región norte de Colombia, se hace una revisión de las características clínicas y el tratamiento, y se describe la epidemiología local de esta enfermedad.


Assuntos
Melioidose/epidemiologia , Amputação Cirúrgica , Antibacterianos/uso terapêutico , Burkholderia pseudomallei/isolamento & purificação , Colômbia/epidemiologia , Diabetes Mellitus Tipo 2/complicações , Doenças do Pé/cirurgia , Humanos , Hospedeiro Imunocomprometido , Falência Renal Crônica/complicações , Masculino , Melioidose/diagnóstico , Melioidose/tratamento farmacológico , Pessoa de Meia-Idade , Cooperação do Paciente , Recidiva , Ribotipagem , Dedos do Pé/microbiologia , Dedos do Pé/cirurgia , Infecções Urinárias/diagnóstico , Infecções Urinárias/tratamento farmacológico , Infecções Urinárias/microbiologia
7.
Med Mycol Case Rep ; 20: 4-6, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30148054

RESUMO

Mucormycosis caused by Apophysomyces variabilis is rarely reported in humans. A case of A. variabilis infection in an immunocompetent men after friction burns in a car accident is described. The infection presented as a rapidly progressive necrotizing infection of the skin and soft tissue, which required extensive surgical debridement and total colonic defunctioning colostomy associated with prolonged antifungal therapy. A. variabilis infection should be considered as a differential diagnosis of rapidly progressive necrotizing skin and soft tissue infections in immunocompetent individuals.

8.
Biomédica (Bogotá) ; Biomédica (Bogotá);43(3): 323-329, sept. 2023. graf
Artigo em Inglês | LILACS | ID: biblio-1533943

RESUMO

Bacteremia by non-O1/non-O139 Vibrio cholerae is a rare entity associated with high mortality rates. We report a case of non-O1/non-O139 V. cholerae bacteremia confirmed by polymerase chain reaction and agglutination tests. The clinicoepidemiological characteristics and therapeutic options for this infection are also described.


La bacteriemia por Vibrio cholerae no-O1/no-O139 es una entidad poco frecuente que se asocia con altas tasas de mortalidad. Se reporta un caso de bacteriemia por V. cholerae no-O1/no-O139 confirmado por reacción en cadena de la polimerasa y test de aglutinación. Se describen las características clinicoepidemiológicas y las opciones terapéuticas para esta infección.


Assuntos
Bacteriemia , Vibrio cholerae não O1 , Fatores de Virulência
9.
Int J Infect Dis ; 49: 107-10, 2016 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-27267577

RESUMO

BACKGROUND: Mucormycosis caused by Saksenaea erythrospora is rarely reported in humans. Three previous cases have been reported in the literature, two associated with trauma (a sailing accident in Argentina and a combat trauma in Iraq) and one as a cause of invasive rhinosinusitis (India), all in immunocompetent patients . The first case of mucormycosis following esthetic surgery, associated with medical tourism, is reported herein. CASE REPORT: A case study of an S. erythrospora infection in an immunocompetent woman after the completion of esthetic surgery (dermolipectomy and breast augmentation) is reported. The infection presented as a rapidly progressive necrotizing infection of the skin and soft tissue, which required a bilateral mastectomy and extensive surgical debridement associated with prolonged antifungal therapy. The organism was identified phenotypically and confirmed biologically after rDNA amplification and sequencing. Two months later, the patient remains hospitalized awaiting the start of reconstructive surgeries. The present case is, to the best of the authors' knowledge, the first report from Colombia. CONCLUSIONS: Mucormycosis should be considered in the differential diagnosis of necrotizing infections of the skin and soft tissue that evolve rapidly after cosmetic surgery performed in tropical or subtropical countries.


Assuntos
Mamoplastia/efeitos adversos , Turismo Médico , Mucormicose/etiologia , Adulto , Estética , Feminino , Humanos , Mucorales/isolamento & purificação
10.
Biomédica (Bogotá) ; Biomédica (Bogotá);39(supl.1): 10-18, mayo 2019. tab, graf
Artigo em Espanhol | LILACS | ID: biblio-1011451

RESUMO

Resumen La melioidosis es una enfermedad infecciosa causada por Burkholderia pseudomallei cuyo diagnóstico clínico puede ser difícil debido a su variada presentación clínica y a las dificultades del diagnóstico microbiológico, por lo cual pueden requerirse técnicas moleculares para su adecuada identificación una vez se sospecha su presencia. Son pocos los antibióticos disponibles para el tratamiento de esta enfermedad y, además, deben usarse durante un tiempo prolongado. Aunque se conoce por ser endémica en Tailandia, Malasia, Singapur, Vietnam y Australia, en Colombia se han reportado algunos pocos casos. Se presenta un caso de melioidosis en la región norte de Colombia, se hace una revisión de las características clínicas y el tratamiento, y se describe la epidemiología local de esta enfermedad.


Abstract Melioidosis is an infectious disease caused by Burkholderia pseudomallei whose clinical diagnosis can be difficult due not only to its varied clinical presentation but also to the difficulties in the microbiological diagnosis.Thus, it may be necessary to use molecular techniques for its proper identification once it is suspected. There are few antibiotics available for the treatment of this disease, which must be used over a long period of time. Although it is known to be endemic in Thailand, Malaysia, Singapore, Vietnam, and Australia, in Colombia there are few reported cases. We describe a case of melioidosis in the northern region of Colombia. Additionally, we review its clinical characteristics and treatment and we describe the local epidemiology of this disease.


Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Melioidose/epidemiologia , Recidiva , Infecções Urinárias/diagnóstico , Infecções Urinárias/microbiologia , Infecções Urinárias/tratamento farmacológico , Dedos do Pé/cirurgia , Dedos do Pé/microbiologia , Cooperação do Paciente , Burkholderia pseudomallei/isolamento & purificação , Hospedeiro Imunocomprometido , Colômbia/epidemiologia , Ribotipagem , Diabetes Mellitus Tipo 2/complicações , Doenças do Pé/cirurgia , Amputação Cirúrgica , Falência Renal Crônica/complicações , Melioidose/diagnóstico , Melioidose/tratamento farmacológico , Antibacterianos/uso terapêutico
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