Detalhe da pesquisa
1.
Ortho group activation of a bromopyrrole ester in Suzuki-Miyaura cross-coupling reactions: Application to the synthesis of new microtubule depolymerizing agents with potent cytotoxic activities.
Bioorg Med Chem
; 25(12): 3206-3214, 2017 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28433513
2.
Biological Characterization of an Improved Pyrrole-Based Colchicine Site Agent Identified through Structure-Based Design.
Mol Pharmacol
; 89(2): 287-96, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26655304
3.
Janus Compounds, 5-Chloro-N4-methyl-N4-aryl-9H-pyrimido[4,5-b]indole-2,4-diamines, Cause Both Microtubule Depolymerizing and Stabilizing Effects.
Molecules
; 21(12)2016 Dec 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27918450
4.
Recent progress with microtubule stabilizers: new compounds, binding modes and cellular activities.
Nat Prod Rep
; 31(3): 335-55, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24481420
5.
The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents.
Bioorg Med Chem
; 22(14): 3753-72, 2014 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24890652
6.
The bat flower: a source of microtubule-destabilizing and -stabilizing compounds with synergistic antiproliferative actions.
J Nat Prod
; 76(10): 1923-9, 2013 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-24087857
7.
Design, Synthesis, and Preclinical Evaluation of 4-Substituted-5-methyl-furo[2,3-d]pyrimidines as Microtubule Targeting Agents That Are Effective against Multidrug Resistant Cancer Cells.
J Med Chem
; 59(12): 5752-65, 2016 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-27213719
8.
AMP-activated protein kinase fortifies epithelial tight junctions during energetic stress via its effector GIV/Girdin.
Elife
; 52016 11 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-27813479
9.
Antiproliferative effects of 12-oxoheteronemin vs heteronemin.
Nat Prod Commun
; 9(3): 359-60, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24689214
10.
Chemically diverse microtubule stabilizing agents initiate distinct mitotic defects and dysregulated expression of key mitotic kinases.
Biochem Pharmacol
; 85(8): 1104-14, 2013 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23399639
11.
Structure-activity relationship and in vitro and in vivo evaluation of the potent cytotoxic anti-microtubule agent N-(4-methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride and its analogues as antitumor agents.
J Med Chem
; 56(17): 6829-44, 2013 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-23895532