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1.
Dermatol Surg ; 46(9): 1183-1189, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-31809349

RESUMO

BACKGROUND: Nanosecond pulsed electric field technology (also known as Nano-Pulse Stimulation or NPS) is a nonthermal, drug-free, energy-based technology that has demonstrated effects on cellular structures of the dermis and epidermis in previous clinical studies. OBJECTIVE: To evaluate the safety and efficacy of a single NPS treatment for clearing seborrheic keratoses (SKs). MATERIALS AND METHODS: This study was a prospective, randomized, open-label, multisite, nonsignificant risk trial in which each subject served as their own control. Fifty-eight subjects had 3 of 4 confirmed SK lesions treated, resulting in 174 total treated lesions. Subjects returned for 5 to 6 follow-up evaluations and photographs. RESULTS: At 106 days after NPS treatment, 82% of treated seborrheic keratoses were rated clear or mostly clear by the assessing physician. Seventy-one percent of lesions were rated clear or mostly clear by the 3 independent reviewers based on the 106-day photographs. All treated subjects returned for all study visits, and 78% of the subjects were satisfied or mostly satisfied with the outcome of the treatment. No adverse events were reported. CONCLUSION: The NPS procedure was well tolerated and effective in the removal of SKs.


Assuntos
Terapia por Estimulação Elétrica/métodos , Ceratose Seborreica/terapia , Adulto , Idoso , Terapia por Estimulação Elétrica/efeitos adversos , Terapia por Estimulação Elétrica/instrumentação , Feminino , Seguimentos , Humanos , Ceratose Seborreica/diagnóstico , Masculino , Pessoa de Meia-Idade , Agulhas/efeitos adversos , Satisfação do Paciente , Fotografação , Estudos Prospectivos , Pele/diagnóstico por imagem , Fatores de Tempo , Resultado do Tratamento
2.
Dermatol Surg ; 46(6): 803-809, 2020 06.
Artigo em Inglês | MEDLINE | ID: mdl-31592824

RESUMO

BACKGROUND: Nanosecond pulsed electric field (nsPEF) technology involves delivery of ultrashort pulses of electrical energy and is a nonthermal, drug-free technology that has demonstrated favorable effects on cellular structures of the dermis and epidermis. OBJECTIVE: Determine the tolerability and effectiveness of nsPEF treatment of sebaceous gland hyperplasia (SGH). METHODS: This study was a prospective, randomized, open-label, multisite, nonsignificant risk trial in which each subject served as their own control. After injection of local anesthetic, high-intensity, ultrashort pulses of electrical energy were used to treat 72 subjects resulting in a total of 222 treated lesions. Subjects returned for 3 to 4 follow-up evaluations with photographs. RESULTS: At the final study visit, 99.6% of treated SGH lesions were rated clear or mostly clear and 79.3% of the subjects were satisfied or mostly satisfied with the outcome. At 60 days after nsPEF treatment, 55% of the lesions were judged to have no hyperpigmentation and 31% exhibited mild post-treatment hyperpigmentation. At the last observation for all lesions, 32% of the 222 lesions were noted as having slight volume loss. CONCLUSION: Nanosecond pulsed electric field procedure is well tolerated and is very effective in the removal of SGHs. TRIAL REGISTRATION: ClinicalTrials.gov NCT03612570.


Assuntos
Terapia por Estimulação Elétrica/métodos , Glândulas Sebáceas/patologia , Adulto , Idoso , Terapia por Estimulação Elétrica/efeitos adversos , Terapia por Estimulação Elétrica/instrumentação , Feminino , Seguimentos , Humanos , Hiperplasia/diagnóstico , Hiperplasia/terapia , Masculino , Pessoa de Meia-Idade , Fotografação , Estudos Prospectivos , Glândulas Sebáceas/diagnóstico por imagem , Índice de Gravidade de Doença , Resultado do Tratamento
3.
Dermatol Surg ; 45(6): 782-790, 2019 06.
Artigo em Inglês | MEDLINE | ID: mdl-30829776

RESUMO

BACKGROUND: The management of skin cancers has evolved with the development of Mohs micrographic surgery and a greater emphasis on surgical training within dermatology. It is unclear whether these changes have translated into innovations and contributions to the reconstructive literature. OBJECTIVE: To assess contributions from each medical specialty to the cutaneous head and neck oncologic reconstructive literature. METHODS: The authors conducted a systematic review of the head and neck reconstructive literature from 2000 through 2015 based on a priori search terms relating to suture technique, linear closure, advancement, rotation, transposition and interpolation flaps, and identified the specialty of the senior authors. RESULTS: The authors identified 74,871 articles, of which 1,319 were relevant. Under suture technique articles, the senior authors were primarily dermatologists (58.2%) and plastic surgeons (20.3%). Under linear closure, the authors were dermatologists (48.1%), plastic surgeons (22.2%), and otolaryngologists (20.4%). Under advancement and rotation flaps, the senior authors were plastic surgeons (40.5%, 38.9%), dermatologists (38.1%, 34.2%), and otolaryngologists (14.4%, 21.6%). Under transposition and interpolation flaps, the senior authors were plastic surgeons (47.3%, 39.4%), dermatologists (32.3%, 27.0%), and otolaryngologists (15.3%, 23.4%). CONCLUSION: The primary specialties contributing to the cutaneous head and neck reconstructive literature are plastic surgery, dermatology, and otolaryngology.


Assuntos
Cirurgia de Mohs/normas , Procedimentos de Cirurgia Plástica/normas , Neoplasias Cutâneas/cirurgia , Retalhos Cirúrgicos/normas , Competência Clínica , Dermatologia/normas , Dermatologia/estatística & dados numéricos , Humanos , Cirurgia de Mohs/métodos , Cirurgia de Mohs/estatística & dados numéricos , Otolaringologia/normas , Otolaringologia/estatística & dados numéricos , Procedimentos de Cirurgia Plástica/métodos , Procedimentos de Cirurgia Plástica/estatística & dados numéricos , Cirurgia Plástica/normas , Cirurgia Plástica/estatística & dados numéricos , Retalhos Cirúrgicos/estatística & dados numéricos , Técnicas de Sutura/normas , Técnicas de Sutura/estatística & dados numéricos , Estados Unidos/epidemiologia , Técnicas de Fechamento de Ferimentos/normas , Técnicas de Fechamento de Ferimentos/estatística & dados numéricos
5.
Dermatol Surg ; 43(10): 1249-1262, 2017 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-28498204

RESUMO

BACKGROUND: Currently, the isotretinoin (13-cis-retinoic acid) package insert contains language advising the discontinuation of isotretinoin for 6 months before performing cosmetic procedures, including waxing, dermabrasion, chemical peels, laser procedures, or incisional and excisional cold-steel surgery. It is common practice to follow this standard because of concerns regarding reports of sporadic adverse events and increased risk of scarring. OBJECTIVE: To develop expert consensus regarding the safety of skin procedures, including resurfacing, energy device treatments, and incisional and excisional procedures, in the setting of concurrent or recent isotretinoin use. MATERIALS AND METHODS: The American Society for Dermatologic Surgery authorized a task force of content experts to review the evidence and provide guidance. First, data were extracted from the literature. This was followed by a clinical question review, a consensus Delphi process, and validation of the results by peer review. RESULTS: The task force concluded that there is insufficient evidence to justify delaying treatment with superficial chemical peels and nonablative lasers, including hair removal lasers and lights, vascular lasers, and nonablative fractional devices for patients currently or recently exposed to isotretinoin. Superficial and focal dermabrasion may also be safe when performed by a well-trained clinician.


Assuntos
Abrasão Química , Dermabrasão , Fármacos Dermatológicos/uso terapêutico , Procedimentos Cirúrgicos Dermatológicos , Isotretinoína/uso terapêutico , Terapia a Laser , Segurança do Paciente/normas , Abrasão Química/efeitos adversos , Cicatriz/etiologia , Cicatriz/prevenção & controle , Dermabrasão/efeitos adversos , Procedimentos Cirúrgicos Dermatológicos/efeitos adversos , Humanos , Terapia a Laser/efeitos adversos , Dermatopatias/etiologia , Dermatopatias/prevenção & controle
7.
Dermatol Surg ; 42(10): 1164-73, 2016 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-27661429

RESUMO

BACKGROUND: The American Council of Graduate Medical Education, which oversees much of postgraduate medical education in the United States, has championed the concept of "milestones," standard levels of achievement keyed to particular time points, to assess trainee performance during residency. OBJECTIVE: To develop a milestones document for the American Society for Dermatologic Surgery (ASDS) Cosmetic Dermatologic Surgery (CDS) fellowship program. METHODS: An ad hoc milestone drafting committee was convened that included members of the ASDS Accreditation Work Group and program directors of ASDS-approved Cosmetic Dermatologic Surgery (CDC) fellowship training programs. Draft milestones were circulated through email in multiple rounds until consensus was achieved. RESULTS: Thirteen milestones were developed in the 6 Accreditation Council for Graduate Medical Education (ACGME) competency areas, with 8 of these being patient-care milestones. Additional instructions for milestone administration more specific to the CDS fellowship than general ACGME instructions were also approved. Implementation of semiannual milestones was scheduled for the fellowship class entering in July 2018. CONCLUSION: Milestones are now available for CDS fellowship directors to implement in combination with other tools for fellow evaluation.


Assuntos
Técnicas Cosméticas , Procedimentos Cirúrgicos Dermatológicos/educação , Educação de Pós-Graduação em Medicina , Bolsas de Estudo , Objetivos Organizacionais , Acreditação , Humanos , Sociedades Médicas , Estados Unidos
9.
J Am Acad Dermatol ; 69(6): 972-1001, 2013 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-24099730

RESUMO

An article titled "Current issues in dermatologic office-based surgery" was published in the JAAD in October 1999 (volume 41, issue 4, pp. 624-634). The article was developed by the Joint American Academy of Dermatology/American Society for Dermatologic Surgery Liaison Committee. A number of subjects were addressed in the article including surgical training program requirements for dermatology residents and selected advances in dermatologic surgery that had been pioneered by dermatologists. The article concluded with sections on credentialing, privileging, and accreditation of office-based surgical facilities. Much has changed since 1999, including more stringent requirements for surgical training during dermatology residency, and the establishment of 57 accredited Procedural Dermatology Fellowship Training Programs. All of these changes have been overseen and approved by the Residency Review Committee for Dermatology and the Accreditation Committee for Graduate Medical Education. The fertile academic environment of academic training programs with interaction between established dermatologic surgeons and fellows, as well as the inquisitive nature of many of our colleagues, has led to the numerous major advances in dermatologic surgery, which are described herein.


Assuntos
Procedimentos Cirúrgicos Dermatológicos , Técnicas de Ablação , Acne Vulgar/complicações , Materiais Biocompatíveis , Certificação , Cicatriz/etiologia , Cicatriz/cirurgia , Dermabrasão , Procedimentos Cirúrgicos Dermatológicos/educação , Procedimentos Cirúrgicos Dermatológicos/métodos , Bolsas de Estudo , Cabelo/transplante , Humanos , Terapia a Laser , Cirurgia de Mohs , Segurança do Paciente , Transtornos da Pigmentação/cirurgia , Procedimentos de Cirurgia Plástica/métodos , Escleroterapia , Dermatopatias/etiologia , Dermatopatias/cirurgia , Tatuagem , Varizes/terapia
12.
Dermatol Surg ; 38(9): 1477-89, 2012 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-22816441

RESUMO

BACKGROUND: Fractionated technology has revolutionized laser therapy. With the success of initial devices, several fractionated lasers have appeared on the market. Claims of superiority have made device choice difficult for physicians and patients. MATERIALS AND METHODS: Twelve subjects were treated with fractionated ablative lasers (10,600-nm carbon dioxide and 2790-nm yttrium scandium gallium garnet) in this institutional review board-approved trial. Each face was divided into four quadrants, and each quadrant was randomly treated using one of four lasers. Clinical experience was used to optimize settings. Two patients submitted biopsies from each quadrant immediately after treatment. Patients and blinded investigators assessed pain during treatment and post-treatment improvement in photoaging (measured by rhytides, lentigines, texture, and pore size) using a five-point scale. RESULTS: All devices resulted in statistical improvement in photoaging in all patients, but no device was statistically significantly superior. No statistically significant difference was found in pain scores. All patients reported satisfaction 1 month after treatment. Three patients experienced adverse reactions. Histologically, there were no statistically significant differences between devices. CONCLUSIONS: Fractionated ablative lasers reliably result in improvement in photoaging. Despite marketing claims, no statistically significant differences were found in outcomes, pain during treatment, or histologic findings. Even with experienced users, significant adverse reactions are possible.


Assuntos
Face/cirurgia , Terapia a Laser/instrumentação , Lasers de Gás/uso terapêutico , Lasers de Estado Sólido/uso terapêutico , Envelhecimento da Pele/patologia , Adulto , Análise de Variância , Feminino , Humanos , Terapia a Laser/efeitos adversos , Lasers de Gás/efeitos adversos , Lasers de Estado Sólido/efeitos adversos , Pessoa de Meia-Idade , Dor/etiologia , Satisfação do Paciente , Fotografação , Método Simples-Cego , Resultado do Tratamento
13.
Front Oncol ; 12: 1044694, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36531070

RESUMO

Background: Nano-Pulse Stimulation™ (NPS™) therapy is a new, non-thermal bioelectric modality that applies ultrashort pulses of electric energy to trigger regulated cell death (RCD) in treated tissues. Instead of initiating necrosis by heating or freezing, NPS therapy permeabilizes intracellular organelles to activate the cell's own self-destruct pathway of programmed or regulated cell death. Unlike cryotherapeutic procedures that can both damage structural tissues and diffuse into the periphery beyond the margins of the lesion, NPS therapy only affects cells within the treated zone leaving surrounding tissue and acellular components unaffected. Methods: In this study we treated 37 basal cell carcinoma lesions on 30 subjects (NCT04918381). The treated lesions were photographed on 3-, 7-, 14-, 30- and 60-days after treatment. All subjects then underwent surgical excision for histological examination of the treated tissue. Results: 92% of the BCC lesions (34 of 37) showed complete histological clearance of BCC. Histologic analysis of the 3 cases where residual BCC was noted indicated that full energy coverage was not achieved, which could be remedied with an improved treatment guide to standardize and optimize the CellFX® procedure based on NPS technology. Conclusion: The CellFX procedure was shown to be safe and effective for the treatment of low-risk nodular and superficial BCC lesions.

17.
J Invest Dermatol ; 126(8): 1745-8, 2006 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-16557237

RESUMO

Pelvic relaxation, a weakening of pelvic support structures, is an under-reported condition that affects a multitude of women. In the United States alone, more than 338,000 procedures for prolapse are performed annually. Decreased collagen content has been noted in the tissues of women affected by this condition. Interestingly, biopsy specimens of women with striae also show a diminution of collagen. Using self-reported anonymous data, we compared the prevalence of striae in women with and without pelvic relaxation to see if an association between these two disorders of connective tissue existed. More than half the women with prolapse (54.7%) (n = 41) reported striae, whereas only 25.0% of women in the non-prolapse group (n = 8) reported striae (P < 0.01). Multivariate logistic regression analysis confirmed striae as a significant risk factor for the development of clinical prolapse (odds ratio 3.12, P < 0.05). There appears to be a strong association between the presence of striae and the development of pelvic relaxation, which is unrelated to conventionally cited risk factors, such as age, weight, number of pregnancies, or postmenopausal status.


Assuntos
Cicatriz/epidemiologia , Cicatriz/patologia , Diafragma da Pelve/patologia , Complicações na Gravidez/epidemiologia , Complicações na Gravidez/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Coleta de Dados , Feminino , Humanos , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Gravidez , Prevalência , Fatores de Risco , Doenças da Bexiga Urinária/epidemiologia , Doenças da Bexiga Urinária/patologia , Prolapso Uterino/epidemiologia , Prolapso Uterino/patologia
18.
Clin Dermatol ; 24(1): 8-15, 2006.
Artigo em Inglês | MEDLINE | ID: mdl-16427501

RESUMO

Laser treatment of vascular lesions remains one of the more common applications of lasers in dermatology. In fact, lasers have largely become the treatment of choice for vascular birthmarks such as hemangiomas and port-wine stains and the definitive treatment of the telangiectatic form of rosacea. The range of congenital and acquired vascular lesions effectively treated with lasers continues to expand.


Assuntos
Terapia a Laser , Dermatopatias Vasculares/radioterapia , Humanos , Telangiectasia/radioterapia
19.
Lasers Surg Med ; 43(2): 63-4, 2011 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-21384384
20.
Semin Cutan Med Surg ; 24(2): 107-12, 2005 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-16092799

RESUMO

Acne vulgaris remains an emotionally and debilitating dermatologic disease, and is conventionally treated with a variety of oral and topical therapies with a number of significant side effects. An evolving understanding of laser-tissue interactions involving Propionibacterium acnes-produced porphyrins, and the development of infrared nonablative lasers to target sebaceous glands, has lead to the development of an escalating number of laser, light and radiofrequency devices for acne. Used as monotherapy or in combination, these devices are showing promise as a method to clear acne in a convenient, non-invasive manner, though there remains a clear need for long-term data and randomized, blinded studies.


Assuntos
Acne Vulgar/terapia , Infecções por Bactérias Gram-Positivas/terapia , Fototerapia/métodos , Propionibacterium acnes/efeitos da radiação , Glândulas Sebáceas/efeitos da radiação , Acne Vulgar/tratamento farmacológico , Humanos , Hipertermia Induzida/métodos , Terapia com Luz de Baixa Intensidade/métodos , Fotoquimioterapia/métodos , Propionibacterium acnes/efeitos dos fármacos , Glândulas Sebáceas/efeitos dos fármacos
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