Detalhe da pesquisa
1.
Structure of lipoprotein lipase in complex with GPIHBP1.
Proc Natl Acad Sci U S A
; 116(21): 10360-10365, 2019 05 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31072929
2.
A small-molecule inhibitor of C5 complement protein.
Nat Chem Biol
; 15(7): 666-668, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31209353
3.
Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton's tyrosine kinase inhibitors.
Bioorg Med Chem
; 44: 116275, 2021 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34314938
4.
Optimization of novel reversible Bruton's tyrosine kinase inhibitors identified using Tethering-fragment-based screens.
Bioorg Med Chem
; 27(13): 2905-2913, 2019 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31138459
5.
Full-length myocilin protein is purified from mammalian cells as a dimer.
Protein Expr Purif
; 147: 38-48, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29475084
6.
Discovery of Darovasertib (NVP-LXS196), a Pan-PKC Inhibitor for the Treatment of Metastatic Uveal Melanoma.
J Med Chem
; 67(2): 1447-1459, 2024 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38198520
7.
Naturally occurring genetic variants of human caspase-1 differ considerably in structure and the ability to activate interleukin-1ß.
Hum Mutat
; 34(1): 122-31, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22833538
8.
Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery.
Bioorg Med Chem Lett
; 21(10): 3078-83, 2011 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21459573
9.
Chemoproteomics Enabled Discovery of Selective Probes for NuA4 Factor BRD8.
ACS Chem Biol
; 16(11): 2185-2192, 2021 11 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34515462
10.
Fragment-based discovery of nonpeptidic BACE-1 inhibitors using tethering.
Biochemistry
; 48(21): 4488-96, 2009 Jun 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-19284778
11.
Water-soluble prodrugs of an Aurora kinase inhibitor.
Bioorg Med Chem Lett
; 19(5): 1409-12, 2009 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19186057
12.
2-Aminobenzimidazoles as potent Aurora kinase inhibitors.
Bioorg Med Chem Lett
; 19(17): 5158-61, 2009 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19646866
13.
Crystal structure of unphosphorylated STAT3 core fragment.
Biochem Biophys Res Commun
; 374(1): 1-5, 2008 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-18433722
14.
Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors.
Bioorg Med Chem Lett
; 18(19): 5186-9, 2008 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18790636
15.
Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors.
Bioorg Med Chem Lett
; 18(20): 5648-52, 2008 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18793847
16.
Discovery of a potent and selective aurora kinase inhibitor.
Bioorg Med Chem Lett
; 18(17): 4880-4, 2008 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18678489
17.
Structure of the Brachydanio rerio Polo-like kinase 1 (Plk1) catalytic domain in complex with an extended inhibitor targeting the adaptive pocket of the enzyme.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 64(Pt 8): 686-91, 2008 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18678933
18.
Crystal structures of a ligand-free and malonate-bound human caspase-1: implications for the mechanism of substrate binding.
Structure
; 12(8): 1361-71, 2004 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-15296730
19.
Structural analysis of caspase-1 inhibitors derived from Tethering.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 61(Pt 5): 451-8, 2005 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16511067
20.
Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases.
Protein Sci
; 19(3): 429-39, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-20052711