Detalhe da pesquisa
1.
Experimentally guided computational antibody affinity maturation with de novo docking, modelling and rational design.
PLoS Comput Biol
; 15(5): e1006980, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31042706
2.
A neutralizing antibody that blocks delivery of the enzymatic cargo of Clostridium difficile toxin TcdB into host cells.
J Biol Chem
; 293(3): 941-952, 2018 01 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-29180448
3.
Structural insights into the mechanism of action of a biparatopic anti-HER2 antibody.
J Biol Chem
; 293(22): 8439-8448, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29669810
4.
Use of a neutralizing antibody helps identify structural features critical for binding of Clostridium difficile toxin TcdA to the host cell surface.
J Biol Chem
; 292(35): 14401-14412, 2017 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28705932
5.
Developability Assessment of Engineered Monoclonal Antibody Variants with a Complex Self-Association Behavior Using Complementary Analytical and in Silico Tools.
Mol Pharm
; 15(12): 5697-5710, 2018 12 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30395473
6.
Green polymer chemistry: investigating the mechanism of radical ring-opening redox polymerization (R3P) of 3,6-dioxa-1,8-octanedithiol (DODT).
Molecules
; 20(4): 6504-19, 2015 Apr 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-25871370
7.
In vivo delivery of engineered synthetic DNA-encoded SARS-CoV-2 monoclonal antibodies for pre-exposure prophylaxis in non-human primates.
Emerg Microbes Infect
; 13(1): 2294860, 2024 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-38165394
8.
Developability profiling of a panel of Fc engineered SARS-CoV-2 neutralizing antibodies.
MAbs
; 15(1): 2152526, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36476037
9.
Qualification of a Biolayer Interferometry Assay to Support AZD7442 Resistance Monitoring.
Microbiol Spectr
; 10(5): e0103422, 2022 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-35993765
10.
Resilience of S309 and AZD7442 monoclonal antibody treatments against infection by SARS-CoV-2 Omicron lineage strains.
Nat Commun
; 13(1): 3824, 2022 07 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35780162
11.
The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in nonhuman primates and has an extended half-life in humans.
Sci Transl Med
; 14(635): eabl8124, 2022 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35076282
12.
DNA-delivered antibody cocktail exhibits improved pharmacokinetics and confers prophylactic protection against SARS-CoV-2.
Nat Commun
; 13(1): 5886, 2022 10 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36202799
13.
In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance.
Commun Biol
; 4(1): 1048, 2021 09 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34497355
14.
Long-acting antibody ligand mimetics for HER4-selective agonism.
Sci Rep
; 10(1): 17257, 2020 10 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33057063
15.
Immune modulator CD70 as a potential cisplatin resistance predictive marker in ovarian cancer.
Gynecol Oncol
; 115(3): 430-7, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19800108
16.
Discovery and characterization of potent IL-21 neutralizing antibodies via a novel alternating antigen immunization and humanization strategy.
PLoS One
; 14(1): e0211236, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30682117
17.
Human Relaxin-2 Fusion Protein Treatment Prevents and Reverses Isoproterenol-Induced Hypertrophy and Fibrosis in Mouse Heart.
J Am Heart Assoc
; 8(24): e013465, 2019 12 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31818212
18.
Design and characterization of homogenous antibody-drug conjugates with a drug-to-antibody ratio of one prepared using an engineered antibody and a dual-maleimide pyrrolobenzodiazepine dimer.
MAbs
; 11(3): 500-515, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30835621
19.
Tumor uptake of pegylated diabodies: Balancing systemic clearance and vascular transport.
J Control Release
; 279: 126-135, 2018 06 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29653224
20.
The role of template-primer in protection of reverse transcriptase from thermal inactivation.
Nucleic Acids Res
; 30(14): 3118-29, 2002 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-12136094