Detalhe da pesquisa
1.
GPAT1 Deficiency in Mice Modulates NASH Progression in a Model-Dependent Manner.
Cell Mol Gastroenterol Hepatol
; 17(2): 279-291, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-37844795
2.
Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis.
J Med Chem
; 65(22): 15000-15013, 2022 11 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-36322383
3.
Inhibition of Acetyl-CoA Carboxylase Causes Malformations in Rats and Rabbits: Comparison of Mammalian Findings and Alternative Assays.
Toxicol Sci
; 179(2): 183-194, 2021 01 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-33247737
4.
ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials.
Nat Med
; 27(10): 1836-1848, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34635855
5.
Pharmacologic inhibition of ketohexokinase prevents fructose-induced metabolic dysfunction.
Mol Metab
; 48: 101196, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33667726
6.
Acetyl-CoA Carboxylase Inhibition Improves Multiple Dimensions of NASH Pathogenesis in Model Systems.
Cell Mol Gastroenterol Hepatol
; 10(4): 829-851, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32526482
7.
De novo lipogenesis is essential for platelet production in humans.
Nat Metab
; 2(10): 1163-1178, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32929234
8.
Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting.
J Med Chem
; 63(19): 10879-10896, 2020 10 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32809824
9.
The combination of exercise training and sodium-glucose cotransporter-2 inhibition improves glucose tolerance and exercise capacity in a rodent model of type 2 diabetes.
Metabolism
; 97: 68-80, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31132381
10.
ß-GPA treatment leads to elevated basal metabolic rate and enhanced hypoxic exercise tolerance in mice.
Physiol Rep
; 5(5)2017 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-28292879
11.
Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK).
J Med Chem
; 60(18): 7835-7849, 2017 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-28853885
12.
The hepatoselective glucokinase activator PF-04991532 ameliorates hyperglycemia without causing hepatic steatosis in diabetic rats.
PLoS One
; 9(5): e97139, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24858947