Detalhe da pesquisa
1.
Direct engagement of the PI3K pathway by mutant KIT dominates oncogenic signaling in gastrointestinal stromal tumor.
Proc Natl Acad Sci U S A
; 114(40): E8448-E8457, 2017 10 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28923937
2.
Imatinib resistance and microcytic erythrocytosis in a KitV558Δ;T669I/+ gatekeeper-mutant mouse model of gastrointestinal stromal tumor.
Proc Natl Acad Sci U S A
; 109(34): E2276-83, 2012 Aug 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22652566
3.
Myosin Light-Chain Kinase Inhibition Potentiates the Antitumor Effects of Avapritinib in PDGFRA D842V-Mutant Gastrointestinal Stromal Tumor.
Clin Cancer Res
; 29(11): 2144-2157, 2023 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36971786
4.
Oncogenic KIT Modulates Type I IFN-Mediated Antitumor Immunity in GIST.
Cancer Immunol Res
; 9(5): 542-553, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33648985
5.
Changes in the structure and function of ICC networks in ICC hyperplasia and gastrointestinal stromal tumors.
Gastroenterology
; 136(2): 630-9, 2009 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-19032955
6.
The V654A second-site KIT mutation increases tumor oncogenesis and STAT activation in a mouse model of gastrointestinal stromal tumor.
Oncogene
; 39(49): 7153-7165, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33024275
7.
FGF signaling targets the pRb-related p107 and p130 proteins to induce chondrocyte growth arrest.
J Cell Biol
; 158(4): 741-50, 2002 Aug 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-12177046
8.
Histone H2AX is a mediator of gastrointestinal stromal tumor cell apoptosis following treatment with imatinib mesylate.
Cancer Res
; 67(6): 2685-92, 2007 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17363589
9.
Oncogenic kinase inhibition limits Batf3-dependent dendritic cell development and antitumor immunity.
J Exp Med
; 216(6): 1359-1376, 2019 06 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31000683
10.
Differential immune profiles distinguish the mutational subtypes of gastrointestinal stromal tumor.
J Clin Invest
; 129(5): 1863-1877, 2019 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30762585
11.
Mitochondrial Inhibition Augments the Efficacy of Imatinib by Resetting the Metabolic Phenotype of Gastrointestinal Stromal Tumor.
Clin Cancer Res
; 24(4): 972-984, 2018 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29246941
12.
Macrophages and CD8+ T Cells Mediate the Antitumor Efficacy of Combined CD40 Ligation and Imatinib Therapy in Gastrointestinal Stromal Tumors.
Cancer Immunol Res
; 6(4): 434-447, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29467128
13.
ETV4 collaborates with Wnt/ß-catenin signaling to alter cell cycle activity and promote tumor aggressiveness in gastrointestinal stromal tumor.
Oncotarget
; 8(69): 114195-114209, 2017 Dec 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29371979
14.
PD-1/PD-L1 Blockade Enhances T-cell Activity and Antitumor Efficacy of Imatinib in Gastrointestinal Stromal Tumors.
Clin Cancer Res
; 23(2): 454-465, 2017 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27470968
15.
Wnt/ß-catenin Signaling Contributes to Tumor Malignancy and Is Targetable in Gastrointestinal Stromal Tumor.
Mol Cancer Ther
; 16(9): 1954-1966, 2017 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28611108
16.
Pharmacological Inhibition of KIT Activates MET Signaling in Gastrointestinal Stromal Tumors.
Cancer Res
; 75(10): 2061-70, 2015 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25836719
17.
Increased KIT inhibition enhances therapeutic efficacy in gastrointestinal stromal tumor.
Clin Cancer Res
; 20(9): 2350-62, 2014 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24583793
18.
KIT oncogene inhibition drives intratumoral macrophage M2 polarization.
J Exp Med
; 210(13): 2873-86, 2013 Dec 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-24323358
19.
Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido.
Nat Med
; 17(9): 1094-100, 2011 Aug 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-21873989
20.
Imatinib upregulates compensatory integrin signaling in a mouse model of gastrointestinal stromal tumor and is more effective when combined with dasatinib.
Mol Cancer Res
; 8(9): 1271-83, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20736294