Detalhe da pesquisa
1.
A host-directed oxadiazole compound potentiates antituberculosis treatment via zinc poisoning in human macrophages and in a mouse model of infection.
PLoS Biol
; 22(4): e3002259, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38683873
2.
The α-tubulin acetyltransferase ATAT1: structure, cellular functions, and its emerging role in human diseases.
Cell Mol Life Sci
; 81(1): 193, 2024 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38652325
3.
Targeting of H19/cell adhesion molecules circuitry by GSK-J4 epidrug inhibits metastatic progression in prostate cancer.
Cancer Cell Int
; 24(1): 56, 2024 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38317193
4.
Transcriptomic and genomic studies classify NKL54 as a histone deacetylase inhibitor with indirect influence on MEF2-dependent transcription.
Nucleic Acids Res
; 50(5): 2566-2586, 2022 03 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35150567
5.
Hydroxamate-based compounds are potent inhibitors of Toxoplasma gondii HDAC biological activity.
Antimicrob Agents Chemother
; 67(11): e0066123, 2023 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37850734
6.
Simultaneous administration of EZH2 and BET inhibitors inhibits proliferation and clonogenic ability of metastatic prostate cancer cells.
J Enzyme Inhib Med Chem
; 38(1): 2163242, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36629431
7.
Antihistamines, phenothiazine-based antipsychotics, and tricyclic antidepressants potently activate pharmacologically relevant human carbonic anhydrase isoforms II and VII.
J Enzyme Inhib Med Chem
; 38(1): 2188147, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36912265
8.
Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression.
Gastroenterology
; 161(5): 1584-1600, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34245764
9.
Biochemical Functions and Clinical Characterizations of the Sirtuins in Diabetes-Induced Retinal Pathologies.
Int J Mol Sci
; 23(7)2022 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35409409
10.
Anti-influenza A virus activity and structure-activity relationship of a series of nitrobenzoxadiazole derivatives.
J Enzyme Inhib Med Chem
; 36(1): 2128-2138, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34583607
11.
Epigenetic polypharmacology: A new frontier for epi-drug discovery.
Med Res Rev
; 40(1): 190-244, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31218726
12.
Identification of Inhibitors to Trypanosoma cruzi Sirtuins Based on Compounds Developed to Human Enzymes.
Int J Mol Sci
; 21(10)2020 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32455951
13.
Effects of Glutathione Transferase-Targeting Nitrobenzoxadiazole Compounds in Relation to PD-L1 Status in Human Melanoma Cells.
Chemotherapy
; 64(3): 138-145, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31639786
14.
Synthesis and characterisation of a new benzamide-containing nitrobenzoxadiazole as a GSTP1-1 inhibitor endowed with high stability to metabolic hydrolysis.
J Enzyme Inhib Med Chem
; 34(1): 1131-1139, 2019 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-31169043
15.
Enzymatic and Biological Characterization of Novel Sirtuin Modulators against Cancer.
Int J Mol Sci
; 20(22)2019 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31726691
16.
H19-Dependent Transcriptional Regulation of ß3 and ß4 Integrins Upon Estrogen and Hypoxia Favors Metastatic Potential in Prostate Cancer.
Int J Mol Sci
; 20(16)2019 Aug 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31426484
17.
Disruptor of telomeric silencing 1-like (DOT1L): disclosing a new class of non-nucleoside inhibitors by means of ligand-based and structure-based approaches.
J Comput Aided Mol Des
; 32(3): 435-458, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29335872
18.
Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC-MEF2 complexes.
EMBO Rep
; 21(12): e51028, 2020 Dec 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33438796
19.
Towards the development of activity-based probes for detection of lysine-specific demethylase-1 activity.
Bioorg Med Chem
; 25(3): 847-856, 2017 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27989416
20.
A new nitrobenzoxadiazole-based GSTP1-1 inhibitor with a previously unheard of mechanism of action and high stability.
J Enzyme Inhib Med Chem
; 32(1): 240-247, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-28097896